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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Cytochrome P4501A1 genetic polymorphisms and breast cancer risk in Nigerian women
Breast Cancer Research and Treatment, Volume 94, No. 3, Year 2005
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Description
In this case-control study based on 250 women with breast cancer and 250 age-matched controls, we sought to evaluate the role of four polymorphic variants in the CYP1A1 gene in breast cancer susceptibility in Nigerian women. Heterozygosity for the CYP1A1 M1 genotype (CYP1A1 M1 [T/C]) was associated with a 21% reduced risk of breast cancer (OR=0.79, 95% CI 0.46-1.40) while homozygosity for the genotype (CYP1A1 M1 [C/C]) conferred a non-significant 9% reduced risk of breast cancer. These risk profiles were not significantly altered in subgroup analysis by menopausal status. While heterozygosity for the CYP1A1 M3 genotype (T/C) conferred a non-significant 24% reduced risk of breast cancer (OR=0.76, 95% CI 0.47-1.22), homozygosity for the variant was associated a non-significant 1.95-fold increased risk of breast cancer (OR=1.95, 95% CI 0.24-6.01). Subgroup analysis showed a non-significant 11% reduced risk in premenopausal heterozygous carriers (OR=0.89, 95% CI 0.45-1.44) and a non-significant 6% increased risk of postmenopausal breast cancer for carriers of the CYP1A1 M3 (T/C) genotype. The CYP1A1 M2 (isoleucine to valine) polymorphism in exon 7 and CYP1A1 M4 (threonine to asparagine) variant in codon 461 of the CYP1A1 gene were found to be very rare in our study subjects. This study has shown that while the CYP1A1 M1 polymorphism conferred reduced risk of breast cancer, homozygosity for the CYP1A1 M3 (C/C) was associated with increased risk of breast cancer although these risks did not attain statistical significance. © Springer 2005.
Authors & Co-Authors
Okobia, Michael N.
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Nigeria, Benin
University of Benin
Bunker, Clareann H.
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Zmuda, Joseph M.
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Kammerer, Candace
United States, Pittsburgh
University of Pittsburgh
Vogel, Victor
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Uche, Emmanuel E.
Nigeria, Port Harcourt
University of Port Harcourt
Anyanwu, Stanley Nnamdi Chinedu
Nigeria, Awka
Nnamdi Azikiwe University
Ezeome, Emmanuel R.
Nigeria, Naukka
University of Nigeria
Ferrell, Robert E.
United States, Pittsburgh
University of Pittsburgh
Kuller, Lewis H.
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Statistics
Citations: 24
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1007/s10549-005-9022-x
ISSN:
01676806
Research Areas
Cancer
Genetics And Genomics
Study Design
Case-Control Study
Participants Gender
Female