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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effects of azithromycin on malariometric indices in The Gambia
The Lancet, Volume 346, No. 8979, Year 1995
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Description
Azithromycin (a macrolide-like antibiotic) has antimalarial effects in vitro and in animal models. In the course of a randomised trial of trachoma control we examined the effects of azithromycin on parasite and spleen rates in the population aged 5-14 years from eight villages in the Farafenni study area in The Gambia, West Africa. The entire population of four treatment villages received three doses of azithromycin 20 mg/kg weekly (days 1, 8, and 15) and four control villages received daily tetracycline eye ointment topically (days 1-42). Among 226 children studied before treatment and at day 28, azithromycin reduced the proportions with Plasmodium falciparumparasites (rate ratio 0·56, 95% confidence interval 0·44-0·71; p<0·0001), with palpable spleens (RR 0.50, 95% Cl 0·36-0·70; p<0·0001), with febrile parasitaemia (RR 0·45, 95% Cl 0·27-0·75; p<0·01), and with P malariae infection (p<0·001). This effect was related more to resolution of parasitaemia than to prevention of new infections. © 1995.
Authors & Co-Authors
Sadiq, Syed Tariq
Unknown Affiliation
Glasgow, K. W.
Unknown Affiliation
Drakely, C. J.
Unknown Affiliation
Mabey, David C.W.
Unknown Affiliation
Bailey, Robin L.
Unknown Affiliation
Müller, Olaf
Unknown Affiliation
Greenwood, Brian M.
Unknown Affiliation
Statistics
Citations: 58
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/S0140-6736(95)92712-3
ISSN:
01406736
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Multi-countries
Gambia