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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cardiac involvement at presentation in patients hospitalized with COVID-19 and their outcome in a tertiary referral hospital in Northern Italy
Internal and Emergency Medicine, Volume 15, No. 8, Year 2020
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Description
The correlation between myocardial injury and clinical outcome in COVID-19 patients is gaining attention in the literature. The aim of the present study was to evaluate the role of cardiac involvement and of respiratory failure in a cohort of COVID-19 patients hospitalized in an academic hospital in Lombardy, one of the most affected Italian (and worldwide) regions by the epidemic. The study included 405 consecutive patients with confirmed COVID-19 admitted to a medical ward from February 25th to March 31st, 2020. Follow-up of surviving patients ended either at hospital discharge or by July 30th, 2020. Myocardial injury was defined on the basis of the presence of blood levels of hs-TnI above the 99th percentile upper reference limit. Respiratory function was assessed as PaO2/FiO2 (P/F) ratio. The primary end-point was death for any cause. During hospitalization, 124 patients died. Death rate increased from 7.9% in patients with normal hs-TnI plasma levels and no cardiac comorbidity to 61.5% in patients with elevated hs-TnI and cardiac involvement (p < 0.001). At multivariable analysis, older age, P/F ratio < 200 (both p < 0.001) and hs-TnI plasma levels were independent predictors of death. However, it must be emphasized that the median values of hs-TnI were within normal range in non-survivors. Cardiac involvement at presentation was associated with poor prognosis in COVID-19 patients, but, even in a population of COVID-19 patients who did not require invasive ventilation at hospital admission, mortality was mainly driven by older age and respiratory failure. © 2020, Società Italiana di Medicina Interna (SIMI).
Authors & Co-Authors
Ghio, Stefano
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Baldi, Enrico
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Italy, Pavia
Università Degli Studi Di Pavia
Vicentini, Alessandro
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Lenti, Marco Vincenzo
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Di Sabatino, Antonio D.
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Zuccaro, Valentina
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Gnecchi, Massimiliano
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Italy, Pavia
Università Degli Studi Di Pavia
Oltrona-Visconti, Luigi
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Perlini, Stefano
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Italy, Pavia
Università Degli Studi Di Pavia
Visconti, Luigi Oltrona
Unknown Affiliation
Ferlini, Marco
Unknown Affiliation
Scelsi, L.
Unknown Affiliation
Montalto, Claudio
Unknown Affiliation
Bruno, R.
Unknown Affiliation
Seminari, Elena Maria
Unknown Affiliation
Tavazzi, Guido
Unknown Affiliation
Albertini, Riccardo
Unknown Affiliation
Klersy, Catherine
Unknown Affiliation
Statistics
Citations: 32
Authors: 18
Affiliations: 2
Identifiers
Doi:
10.1007/s11739-020-02493-y
ISSN:
18280447
Research Areas
Covid
Health System And Policy
Noncommunicable Diseases
Violence And Injury
Study Design
Cross Sectional Study
Cohort Study