Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Indicators of mortality in African adults with malaria
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 100, No. 8, Year 2006
Notification
URL copied to clipboard!
Description
Malaria is a major cause of morbidity and mortality amongst adults in sub-Saharan Africa, but descriptions of symptoms and mortality in this group have received little attention in the past. A retrospective study was performed on adults admitted to a tertiary hospital in Tanzania with a primary diagnosis of malaria. Frequency and mortality for the criteria in the WHO definition of severe malaria were recorded. Logistic regression analysis was then used to identify symptoms with the greatest prognostic value. Two hundred and sixty-nine adults (median age 28 years) with a primary diagnosis of malaria were studied, with an overall mortality rate of 15.2%. Logistic regression identified three key prognostic indicators: unconsciousness (odds ratio (OR) 44.44; 95% CI 4.05-488.24), renal failure (OR 7.37; 95% CI 1.70-31.96) and pulmonary oedema (OR 13.83; 95% CI 3.52-54.32). Whilst the WHO criteria predicted all of the 41 adults who died, 37 (90.2%) had at least one of the following symptoms: unconsciousness (n = 39, fatality rate 74.4%), renal failure (n = 26, fatality rate 66.7%) and pulmonary oedema (n = 28, fatality rate 64.3%). These symptoms can therefore identify those at a high risk of death in African adults with malaria. © 2006 Royal Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Robinson, Tim
United Kingdom, Nottingham
University of Nottingham Medical School
Mosha, Franklin W.
Tanzania, Moshi
Kilimanjaro Christian Medical Centre
Grainge, Matthew J.
United Kingdom, Nottingham
University of Nottingham Medical School
Madeley, Richard
United Kingdom, Nottingham
University of Nottingham Medical School
Statistics
Citations: 24
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/j.trstmh.2005.12.004
ISSN:
00359203
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cohort Study
Case-Control Study
Study Approach
Quantitative
Study Locations
Tanzania