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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Probiotics, feeding tolerance, and growth: A comparison between HIV-exposed and unexposed very low birth weight infants
Nutrition, Volume 30, No. 6, Year 2014
Notification
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Description
Objective: The aim of this study was to compare the effect of administration of probiotics on feeding tolerance and growth outcomes of HIV-exposed (but uninfected) versus HIV non-exposed preterm infants. The null hypothesis of this study states that there will be no difference in the feeding tolerance and growth outcomes for both probiotic-exposed and unexposed premature very low birth weight infants. Methods: A randomized, double-blind, placebo-controlled trial was conducted during the period from July 2011 to August 2012. HIV-exposed and non-exposed premature (<34 wk gestation) infants with a birth weight of ≥500 g and ≤1250 g were randomized to receive either a probiotic mixture or placebo. The multispecies probiotic mixture consisted of 1 × 109 CFU, Lactobacillus rhamnosus GG and Bifidobacterium infantis per day and was administered for 28 d. Anthropometrical parameters, daily intakes, and feeding tolerance were monitored. Results: Seventy-four HIV-exposed and 110 unexposed infants were enrolled and randomized (mean birth weight 987 g ± 160 g, range, 560-1244 g; mean gestational age 28.7 wk). In all 4227 probiotic doses were administered (mean 22.9/infant). There was no difference in the average daily weight gain for treatment groups or HIV exposure. The HIV-exposed group achieved significantly higher z scores for length and head circumference at day 28 than the unexposed group (P < 0.01 and P = 0.03, respectively). There were no differences in the incidence of any signs of feeding intolerance and abdominal distension between the groups. Conclusion: Probiotic supplementation did not affect growth outcomes or the incidence of any signs of feeding intolerance in HIV exposure. © 2014 Elsevier Inc.
Authors & Co-Authors
van Niekerk, Evette
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Kirsten, Gerhardus Francois
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Nel, Daniel Gerhardus
South Africa, Stellenbosch
Stellenbosch University
Blaauw, Reneé
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Statistics
Citations: 26
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/j.nut.2013.10.024
ISSN:
08999007
e-ISSN:
18731244
Research Areas
Disability
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study