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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Association of the insertion/deletion gene polymorphism of the apolipoprotein B signal peptide with myocardial infarction in Tunisian patients
Clinical Chemistry and Laboratory Medicine, Volume 46, No. 8, Year 2008
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Description
Background: Numerous polymorphisms of the apolipoprotein B (APOB) gene have been described. Particularly, the insertion/deletion (Ins/Del) polymorphism located in the coding part of the signal peptide of apoB, associated with modification of lipid concentrations and the risk of coronary artery disease and/or myocardial infarction (MI), has been reported in the general population. Moreover, conflicting results emerge from the literature and suggest that the effect is context-dependent. In the present study, the first investigation of the Ins/Del polymorphism of the APOB gene in Tunisian patients with MI, we examined a possible association between this polymorphism and MI in a subgroup of the Tunisian population. Methods: A total of 318 Tunisian patients with MI and 368 healthy controls were included in the study. Genomic DNA was extracted from white blood cells, and the Ins/Del polymorphism was determined by electrophoresis in polyacrylamide gels after PCR amplification. A binary logistic regression analysis was performed to test how the association between MI and Ins/Del polymorphism is independent from confounding factors. Results: A significant difference in genotype distribution and allele frequency was observed between patients and controls. Patients with MI had a frequency of 7.2% for the Del/Del genotype, 39.6% for the Ins/Del genotype, and 53.1% for the Ins/Ins genotype. Controls had a frequency of 3.0% for the Del/Del, 32.1% for the Ins/Del and 64.9% for the Ins/Ins genotype (χ2=12.93, p=0.002). The MI patient group showed a significantly higher frequency of the Del allele compared to controls (27.1% vs. 19.1%; χ2=12.50, p=0.0004). In comparison to the Ins/Ins homozygotes, the odds ratio (95% confidence interval) for MI was 1.51 (1.09-2.07) for Ins/Del heterozygotes and 2.95 (1.40-6.22) for Del/Del homozygotes. In multivariate analysis, age (p=0.001), smoking (p<0.001), hypertension (p=0.001), diabetes mellitus (p<0.001), and dyslipidemia (p=0.01) were independent correlates of the presence of MI, whereas the Ins/Del polymorphism (p=0.330) was not an independent predictor of MI. Conclusions: The present study shows a significant but not independent association between the Ins/Del polymorphism of the APOB gene and MI in the Tunisian population. © 2008 by Walter de Gruyter.
Authors & Co-Authors
Kallel, Amani
Tunisia, Tunis
Hôpital la Rabta
Ben Ali, Samir
Tunisia, Tunis
Hôpital la Rabta
Sédiri, Yousra
Tunisia, Tunis
Hôpital la Rabta
Chabrak, Sonia
Tunisia, Tunis
Hôpital la Rabta
Allal-Elasmi, Monia
Tunisia, Tunis
Hôpital la Rabta
Sanhaji, Haïfa
Tunisia, Tunis
Hôpital la Rabta
Souheil, Omar
Tunisia, Tunis
Hôpital la Rabta
Haj-Taïeb, Sameh
Tunisia, Tunis
Hôpital la Rabta
Feki, Moncef
Tunisia, Tunis
Hôpital la Rabta
Mechmèche, Rachid
Tunisia, Tunis
Hôpital la Rabta
Jemaa, Riadh
Tunisia, Tunis
Hôpital la Rabta
Kâabachi, Naziha
Tunisia, Tunis
Hôpital la Rabta
Statistics
Citations: 12
Authors: 12
Affiliations: 1
Identifiers
Doi:
10.1515/CCLM.2008.215
ISSN:
14346621
e-ISSN:
14374331
Research Areas
Genetics And Genomics
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study
Case-Control Study
Study Approach
Quantitative