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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
High frequency, sustained T cell responses to PARV4 suggest viral persistence in vivo
Journal of Infectious Diseases, Volume 203, No. 10, Year 2011
Notification
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Description
Background. Parvovirus 4 (PARV4) is a recently identified human virus that has been found in livers of patients infected with hepatitis C virus (HCV) and in bone marrow of individuals infected with human immunodeficiency virus (HIV). T cells are important in controlling viruses but may also contribute to disease pathogenesis. The interaction of PARV4 with the cellular immune system has not been described. Consequently, we investigated whether T cell responses to PARV4 could be detected in individuals exposed to blood-borne viruses. Methods. Interferon γ (IFN-γ) enzyme-linked immunospot assay, intracellular cytokine staining, and a tetrameric HLA-A*0201-peptide complex were used to define the lymphocyte populations responding to PARV4 NS peptides in 88 HCV-positive and 13 HIV-positive individuals. Antibody responses were tested using a recently developed PARV4 enzyme-linked immunosorbent assay. Results. High-frequency T cell responses against multiple PARV4 NS peptides and antibodies were observed in 26% of individuals. Typical responses to the NS pools were 7gt;1000 spot-forming units per million peripheral blood mononuclear cells. Conclusions. PARV4 infection is common in individuals exposed to blood-borne viruses and elicits strong T cell responses, a feature typically associated with persistent, contained infections such as cytomegalovirus. Persistence of PARV4 viral antigen in tissue in HCV-positive and HIV-positive individuals and/or the associated activated antiviral T cell response may contribute to disease pathogenesis. © The Author 2011.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3080894/bin/supp_203_10_1378_v2_index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3080894/bin/supp_jir036_SuppTable.doc
Authors & Co-Authors
Simmons, Ruth D.
United Kingdom, Oxford
University of Oxford
Sharp, Colin P.
United Kingdom, Edinburgh
The University of Edinburgh
Sims, Stuart
United Kingdom, Edinburgh
The University of Edinburgh
Kløverpris, Henrik N.
United Kingdom, Oxford
University of Oxford
Goulder, Philip Jeremy Renshaw
United Kingdom, Oxford
University of Oxford
Simmonds, Peter N.
United Kingdom, Edinburgh
The University of Edinburgh
Bowness, Paul
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
United Kingdom, Oxford
Nihr Oxford Health Biomedical Research Centre
Klenerman, Paul
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Health Biomedical Research Centre
Statistics
Citations: 38
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1093/infdis/jir036
ISSN:
00221899
Research Areas
Infectious Diseases