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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of intratympanic dexamethasone administration on cisplatin-induced ototoxicity in adult guinea pigs
Auris Nasus Larynx, Volume 40, No. 1, Year 2013
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Description
Objective: To evaluate the effect and safety of intratympanic dexamethasone administration on cisplatin-induced ototoxicity in adult male guinea pigs and to assess the differences between early and late protection from this ototoxicity. Methods: Forty eight adult male guinea pigs were divided as follows: group I served as control group. Group II was subjected to intratympanic saline (subgroup IIa) or dexamethasone (subgroup IIb) injection. Group III was intraperitoneally injected with cisplatin. Groups IV and V were subjected first to intratympanic dexamethasone administration in both ears for 5 days starting 1 day and 1. h - respectively - before cisplatin intraperitoneal injection. Results: Dexamethasone intratympanic injection revealed similar functional and structural results compared with control. Cisplatin intraperitoneal injection resulted in a profound cochlear functional and structural damage in group III. Non-significant otoprotection resulted from intratympanic dexamethasone administration one day before cisplatin. Intratympanic dexamethasone injection 1. h before cisplatin treatment resulted in a significant preservation of the functional and structural properties of the cochlea. Conclusion: Intratympanic dexamethasone administration is a safe, easy and efficient way to protect from cisplatin ototoxicity especially when administered 1. h before cisplatin treatment. © 2012 Elsevier Ireland Ltd.
Authors & Co-Authors
Shafik, Amr Gouda
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Elkabarity, Rasha H.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Thabet, Mirahan T.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Bahaa, Nevine
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Kalleny, Nagwa Kostandy
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Statistics
Citations: 30
Authors: 5
Affiliations: 1
Identifiers
Doi:
10.1016/j.anl.2012.05.010
ISSN:
03858146
e-ISSN:
18791476
Study Design
Randomised Control Trial
Study Locations
Guinea
Participants Gender
Male