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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Genetic and household determinants of predisposition to human hookworm infectionin a Brazilian community
Journal of Infectious Diseases, Volume 202, No. 6, Year 2010
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Description
Background: Predisposition to heavy or light human hookworm infection is consistently reported in treatmentreinfection studies. A significant role for host genetics in determining hookworm infection intensity has also been shown, but the relationship between host genetics and predisposition has not been investigated. Methods: A treatment-reinfection study was conducted among 1302 individuals in Brazil. Bivariate variance components analysis was used to estimate heritability for pretreatment and reinfection intensity and to estimate the contribution of genetic and household correlations between phenotypes to the overall phenotypic correlation (ie, predisposition). Results: Heritability for hookworm egg count was 17% before treatment and 25% after reinfection. Predisposition to heavy or light hookworm infection was observed, with a phenotypic correlation of 0.34 between pretreatment and reinfection intensity. This correlation was reduced to 0.23 after including household and environmental covariates. Genetic and household correlations were 0.41 and 1, respectively, and explained 88% of the adjusted phenotypic correlation. Conclusions: Predisposition to human hookworm infection in this area results from a combination of host genetics and consistent differences in exposure, with the latter explained by household and environmental factors. Unmeasured individual-specific differences in exposure did not contribute to predisposition. © 2010 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Quinnell, Rupert J.
Unknown Affiliation
Pullan, Rachel L.
Unknown Affiliation
Breitling, Lutz Ph
Unknown Affiliation
Geiger, Stefan Michael
Unknown Affiliation
Cundill, Bonnie
Unknown Affiliation
Côrrea-Oliveira, Rodrigo
Unknown Affiliation
Brooker, Simon J.
Unknown Affiliation
Bethony, Jeffrey Michael
Unknown Affiliation
Statistics
Citations: 27
Authors: 8
Affiliations: 7
Identifiers
Doi:
10.1086/655813
ISSN:
00221899
Research Areas
Genetics And Genomics