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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
AM404 attenuates reinstatement of nicotine seeking induced by nicotine-associated cues and nicotine priming but does not affect nicotine- and food-taking
Journal of Psychopharmacology, Volume 27, No. 6, Year 2013
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Description
Multiple studies suggest a pivotal role of the endocannabinoid system in the regulation of the reinforcing effects of various substances of abuse. Different approaches have been used to modulate endocannabinoid neurotransmission including the use of endogenous cannabinoid anandamide reuptake inhibitors. Previously, the effects of one of them, N-(4-hydroxyphenyl)-arachidonamide (AM404), have been explored in rodents trained to self-administer ethanol and heroin, producing some promising results. Moreover, AM404 attenuated the development and reinstatement of nicotine-induced conditioned place preference (CPP). In this study, we used the nicotine intravenous self-administration procedure to assess the effects of intraperitoneal administration of 0, 1, 3 and 10 mg/kg AM404 on nicotine-taking and food-taking behaviors under fixed-ratio and progressive-ratio schedules of reinforcement, as well as on reinstatement of nicotine-seeking induced by nicotine priming and by presentation of nicotine-associated cues. The ability of AM404 to produce place preference was also evaluated. AM404 did not produce CPP and did not modify nicotine-taking and food-taking behaviors. In contrast, AM404 dose-dependently attenuated reinstatement of nicotine-seeking behavior induced by both nicotine-associated cues and nicotine priming. Our results indicate that AM404 could be a potential promising therapeutic option for the prevention of relapse to nicotine-seeking in abstinent smokers. © The Author(s) 2013.
Authors & Co-Authors
Gamaleddin, Islam
Canada, Toronto
Centre for Addiction and Mental Health
Egypt, Cairo
Ain Shams University
Guranda, Mihail
Canada, Toronto
Centre for Addiction and Mental Health
Scherma, Maria
United States, Baltimore
National Institute of Drug Abuse Nida
Italy, Cagliari
Università Degli Studi Di Cagliari
Fratta, Walter
Italy, Cagliari
Università Degli Studi Di Cagliari
Makriyannis, Alexandros M.
United States, Boston
Northeastern University
Vadivel, Subramanian K.
United States, Boston
Northeastern University
Goldberg, Steven R.
United States, Baltimore
National Institute of Drug Abuse Nida
Le Foll, Bernard
Canada, Toronto
Centre for Addiction and Mental Health
Canada, Toronto
University of Toronto
Statistics
Citations: 31
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1177/0269881113477710
ISSN:
02698811
e-ISSN:
14617285
Research Areas
Food Security