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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Worldwide patterns of genomic variation and admixture in gray wolves
Genome Research, Volume 26, No. 2, Year 2016
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Description
The gray wolf (Canis lupus) is a widely distributed top predator and ancestor of the domestic dog. To address questions about wolf relationships to each other and dogs, we assembled and analyzed a data set of 34 canine genomes. The divergence between New and Old World wolves is the earliest branching event and is followed by the divergence of OldWorld wolves and dogs, confirming that the dog was domesticated in the Old World. However, no single wolf population is more closely related to dogs, supporting the hypothesis that dogs were derived from an extinct wolf population. All extant wolves have a surprisingly recent common ancestry and experienced a dramatic population decline beginning at least ∼30 thousand years ago (kya). We suggest this crisis was related to the colonization of Eurasia by modern human hunter-gatherers, who competed with wolves for limited prey but also domesticated them, leading to a compensatory population expansion of dogs. We found extensive admixture between dogs and wolves, with up to 25% of Eurasian wolf genomes showing signs of dog ancestry. Dogs have influenced the recent history of wolves through admixture and vice versa, potentially enhancing adaptation. Simple scenarios of dog domestication are confounded by admixture, and studies that do not take admixture into account with specific demographic models are problematic. © 2016 Fan et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4728369/bin/supp_26_2_163__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC4728369/bin/supp_gr.197517.115_SuppFigures.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC4728369/bin/supp_gr.197517.115_SuppInformation.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC4728369/bin/supp_gr.197517.115_SuppTable_1.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC4728369/bin/supp_gr.197517.115_SuppTable_2.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC4728369/bin/supp_gr.197517.115_SuppTable_3.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC4728369/bin/supp_gr.197517.115_SuppTable_4.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC4728369/bin/supp_gr.197517.115_SuppTable_5.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC4728369/bin/supp_gr.197517.115_SuppTable_6.docx
Authors & Co-Authors
Fan, Zhenxin
China, Beijing
Ministry of Education of the People's Republic of China
United States, Los Angeles
University of California, Los Angeles
Silva, Pedro M.
Portugal, Porto
Universidade do Porto
Schweizer, Rena M.
United States, Los Angeles
University of California, Los Angeles
Ramírez, Oscar
Spain, Barcelona
Csic-upf - Instituto de Biologia Evolutiva Ibe
Pollinger, John P.
United States, Los Angeles
University of California, Los Angeles
Galaverni, Marco
Italy, Rome
Italian Institute for Environmental Protection and Research
Ortega-Del Vecchyo, Diego
United States, Los Angeles
University of California, Los Angeles
Xing, Jinchuan
United States, New Brunswick
Rutgers University–new Brunswick
Vilà, Carles
Spain, Barcelona
Universitat de Barcelona
Marques-Bonet, Tomas
Spain, Barcelona
Csic-upf - Instituto de Biologia Evolutiva Ibe
Spain, Barcelona
Universitat de Barcelona
Godinho, Raquel
Portugal, Porto
Universidade do Porto
Yue, Bisong
China, Beijing
Ministry of Education of the People's Republic of China
Wayne, Robert K.
United States, Los Angeles
University of California, Los Angeles
Statistics
Citations: 132
Authors: 13
Affiliations: 10
Identifiers
Doi:
10.1101/gr.197517.115
ISSN:
10889051
Study Design
Cross Sectional Study