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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer
Nature Genetics, Volume 41, No. 8, Year 2009
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Description
An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that the region harboring this variant is a transcriptional enhancer, that the alleles of rs6983267 differentially bind transcription factor 7-like 2 (TCF7L2) and that the risk region physically interacts with the MYC proto-oncogene. These data provide strong support for a biological mechanism underlying this non-protein-coding risk variant. © 2009 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Pomerantz, Mark M.
United States, Boston
Dana-farber Cancer Institute
Doddapaneni, Harshavardhan
United States, Iowa City
University of Iowa
Chan, Jennifer A.W.
Canada, Calgary
University of Calgary
Haiman, Christopher A.
United States, Los Angeles
Keck School of Medicine of Usc
Henderson, Brian E.
United States, Los Angeles
Keck School of Medicine of Usc
Barretina, Jordi G.
United States, Boston
Dana-farber Cancer Institute
Tabernero, Josep Ma
Spain, Barcelona
Hospital Universitari Vall D'hebron
Baselga, José M.
Spain, Barcelona
Hospital Universitari Vall D'hebron
Regan, Meredith M.
United States, Boston
Dana-farber Cancer Institute
Manak, John Robert
United States, Iowa City
University of Iowa
Coetzee, Gerhard A.
United States, Los Angeles
Keck School of Medicine of Usc
Freedman, Matthew Lee
United States, Boston
Dana-farber Cancer Institute
United States, Cambridge
Broad Institute
Statistics
Citations: 563
Authors: 12
Affiliations: 7
Identifiers
Doi:
10.1038/ng.403
ISSN:
15461718
Research Areas
Cancer