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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Maternal vitamin A deficiency and mother-to-child transmission of HIV-1
The Lancet, Volume 343, No. 8913, Year 1994
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Description
Summary. Studies show that around 10-40% HIV-positive women will give birth to children who are also infected. However, the risk factors for transmission from mother to child are not well understood and the effects of maternal nutritional status are unknown. We conducted a study of vitamin A status in pregnant women as a risk factor for mother-to-child transmission of HIV in Malawi. Serum vitamin A, height, weight, CD4 T-cell counts, and duration of breastfeeding were measured in 338 HIV-positive mothers whose infant's HIV serostatus was known. Mother-to-child transmission of HIV was 21 9% among mothers whose infants survived to 12 months of age. Mean vitamin A concentration in 74 mothers who transmitted HIV to their infants was lower than that in 264 mothers who did not transmit HIV to their infants (0·86 [0 03] vs 1·07 [0 02], p<0·0001). We divided HIV positive mothers to 4 groups, those with vitamin A concentrations of less than 0 70, between 0·70 and 1·05, between 1 05 and 1·40, and greater than or equal to 1 40 μmol/L. The mother-to-child transmission rates for each group were 32·4%, 26 2%, 16·0%, and 7·2%, respectively (p<0·0001). Maternal CD4 cell counts, CD4%, and CD4/CD8 ratio were also associated with increased mother-to-child transmission of HIV. Maternal age, body-mass index, and breastfeeding practices were not significantly associated with higher mother-to-child transmission. Our study suggests that maternal vitamin A deficiency contributes to mother-to-child transmission of HIV. © 1994.
Authors & Co-Authors
Semba, Richard D.
United States, Baltimore
Division of Nutrition
Chiphangwi, John D.
Malawi, Zomba
University of Malawi
Miotti, Paolo G.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Dallabetta, Gina A.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Hoover, Donald R.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Canner, Joseph K.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Saah, Alfred I.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Statistics
Citations: 411
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/S0140-6736(94)93056-2
ISSN:
01406736
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Malawi
Participants Gender
Female