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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Abnormal glucose tolerance in βthalassemia: Assessment of risk factors
Hemoglobin, Volume 33, No. 2, Year 2009
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Description
In βthalassemia β-thal) major, the pathogenetic mechanisms leading from siderosis to diabetes are poorly understood. We assessed the glycometabolic status in transfusion-dependent Egyptian 0-thal patients and evaluated their possible risk factors for abnormal glucose tolerance (AGT). An oral glucose tolerance test (OGTT) was done on 54 multi-transfused patients and 28 age-matched normal controls, measuring their serum insulin levels at 0 and 120 min. Insulin sensitivity and insulin release indices were calculated. Indicators of iron overload and liver status were recorded. Thirteen patients (24.1%) had AGT. Cases with AGT had significantly higher mean postprandial insulin, fasting insulin resistance index (FIIU) and homeostasis model assessment (HOMA) insulin resistance (IK), p = 0.0001 for all, and significantly lower mean HOMA (β cell, p = 0.007, when compared with normal glucose tolerance (NGT) cases. Abnormal glucose tolerance is common in multi-transfused (β-thal major patients and could be attributed to early impaired β-cell function with increasing IK © Informa Healthcare USA, Inc.
Authors & Co-Authors
Hafez, Mona Hassan
Egypt, Cairo
Faculty of Medicine
Youssry, Ilham
Egypt, Cairo
Faculty of Medicine
El-Hamed, Fayza Abd
Egypt, Cairo
Faculty of Medicine
Ibrahim, Amany Ahmad
Egypt, Cairo
Faculty of Medicine
Statistics
Citations: 39
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1080/03630260902817131
ISSN:
03630269
e-ISSN:
1532432X
Research Areas
Health System And Policy
Noncommunicable Diseases