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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Testosterone, sex hormone-binding globulin and the metabolic syndrome in men: An individual participant data meta-analysis of observational studies
PLoS ONE, Volume 9, No. 7, Article e100409, Year 2014
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Description
Background: Low total testosterone (TT) and sex hormone-binding globulin (SHBG) concentrations have been associated with the metabolic syndrome (MetS) in men, but the reported strength of association varies considerably. Objectives: We aimed to investigate whether associations differ across specific subgroups (according to age and body mass index (BMI)) and individual MetS components. Data sources: Two previously published meta-analyses including an updated systematic search in PubMed and EMBASE. Study Eligibility Criteria: Cross-sectional or prospective observational studies with data on TT and/or SHBG concentrations in combination with MetS in men. Methods: We conducted an individual participant data meta-analysis of 20 observational studies. Mixed effects models were used to assess cross-sectional and prospective associations of TT, SHBG and free testosterone (FT) with MetS and its individual components. Multivariable adjusted odds ratios (ORs) and hazard ratios (HRs) were calculated and effect modification by age and BMI was studied. Results: Men with low concentrations of TT, SHBG or FT were more likely to have prevalent MetS (ORs per quartile decrease were 1.69 (95% CI 1.60-1.77), 1.73 (95% CI 1.62-1.85) and 1.46 (95% CI 1.36-1.57) for TT, SHBG and FT, respectively) and incident MetS (HRs per quartile decrease were 1.25 (95% CI 1.16-1.36), 1.44 (95% 1.30-1.60) and 1.14 (95% 1.01-1.28) for TT, SHBG and FT, respectively). Overall, the magnitude of associations was largest in non-overweight men and varied across individual components: stronger associations were observed with hypertriglyceridemia, abdominal obesity and hyperglycaemia and associations were weakest for hypertension. Conclusions: Associations of testosterone and SHBG with MetS vary according to BMI and individual MetS components. These findings provide further insights into the pathophysiological mechanisms linking low testosterone and SHBG concentrations to cardiometabolic risk. © 2014 Brand et al.
Authors & Co-Authors
Brand, Judith S.
Netherlands, Utrecht
University Medical Center Utrecht
Rovers, Maroeska M.
Netherlands, Utrecht
University Medical Center Utrecht
Netherlands, Nijmegen
Radboud University Medical Center
Yeap, Bu Beng
Australia, Perth
University of Western Australia, School of Medicine and Pharmacology
Schneider, Harald Jörn
Germany, Munich
Klinikum Der Universität München
Tuomainen, Tomi Pekka
Finland, Kuopio
Itä-suomen Yliopisto
Haring, Robin
Germany, Greifswald
Universitätsmedizin Greifswald
Corona, Giovanni
Italy, Florence
Università Degli Studi Di Firenze
Onat, Altan
Turkey, Istanbul
Istanbul Üniversitesi
Maggio, Marcello Giuseppe
Italy, Parma
Università Di Parma
Bouchard, Claude E.
United States, Baton Rouge
Pennington Biomedical Research Center
Tong, Peter Chun Yip
Hong Kong, Hong Kong
Chinese University of Hong Kong
Chen, Richard Yuan Tud
Singapore, Singapore City
General Hospital
Akishita, Masahiro
Japan, Tokyo
Graduate School of Medicine
Gietema, Jourik A.
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Gannagé-Yared, Marie Hélène
Lebanon, Beirut
Université Saint-joseph de Beyrouth
Undën, Anna Lena
Sweden, Stockholm
Center for Epidemiology and Community Medicine
Hautanen, Aarno
Finland, Helsinki
Helsingin Yliopisto
Goncharov, Nikolai Petrovich
Russian Federation, Moscow
Endocrinology Research Centre
Kumanov, Philip T.
Bulgaria, Sofia
Medical University of Sofia
Chubb, Stephen Anthony Paul
Australia, Perth
University of Western Australia, School of Medicine and Pharmacology
Almeida, Osvaldo P.
Australia, Perth
The University of Western Australia
Wïttchen, Hans Ülrich
Germany, Dresden
Technische Universität Dresden
Klotsche, Jens
Germany, Dresden
Technische Universität Dresden
Wallaschofski, Henri
Germany, Greifswald
Universitätsmedizin Greifswald
Völzke, Henry
Germany, Greifswald
Universitätsmedizin Greifswald
Kauhanen, Jussi
Finland, Kuopio
Itä-suomen Yliopisto
Salonen, Jukka T.S.
Finland, Helsinki
Mas-metabolic Analytical Services oy
Ferrucci, Luigi G.
United States, Bethesda
National Institute on Aging Nia
van der Schouw, Y. T.
Netherlands, Utrecht
University Medical Center Utrecht
Statistics
Citations: 177
Authors: 29
Affiliations: 23
Identifiers
Doi:
10.1371/journal.pone.0100409
e-ISSN:
19326203
Research Areas
Environmental
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Systematic review
Participants Gender
Male