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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Effectiveness of the Viet Nam Produced, Mouse Brain-Derived, Inactivated Japanese Encephalitis Vaccine in Northern Viet Nam
PLoS Neglected Tropical Diseases, Volume 6, No. 12, Article e1952, Year 2012
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Description
Background: Japanese encephalitis (JE) is a flaviviral disease of public health concern in many parts of Asia. JE often occurs in large epidemics, has a high case-fatality ratio and, among survivors, frequently causes persistent neurological sequelae and mental disabilities. In 1997, the Vietnamese government initiated immunization campaigns targeting all children aged 1-5 years. Three doses of a locally-produced, mouse brain-derived, inactivated JE vaccine (MBV) were given. This study aims at evaluating the effectiveness of Viet Nam's MBV. Methodology: A matched case-control study was conducted in Northern Viet Nam. Cases were identified through an ongoing hospital-based surveillance. Each case was matched to four healthy controls for age, gender, and neighborhood. The vaccination history was ascertained through JE immunization logbooks maintained at local health centers. Principal Findings: Thirty cases and 120 controls were enrolled. The effectiveness of the JE vaccine was 92.9% [95% CI: 66.6-98.5]. Confounding effects of other risk variables were not observed. Conclusions: Our results strongly suggest that the locally-produced JE-MBV given to 1-5 years old Vietnamese children was efficacious. © 2012 Marks et al.
Authors & Co-Authors
Marks, Florian
South Korea, Seoul
International Vaccine Institute, Seoul
Yen, Nguyen Thi
Viet Nam, Hanoi
National Institute of Hygiene and Epidemiology Hanoi
Meyer, Christian G.
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
You, Young-ae
South Korea, Seoul
International Vaccine Institute, Seoul
Konings, Frank
South Korea, Seoul
International Vaccine Institute, Seoul
Wierzba, Thomas F.
South Korea, Seoul
International Vaccine Institute, Seoul
Xu, Zhiyi
South Korea, Seoul
International Vaccine Institute, Seoul
Statistics
Citations: 8
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pntd.0001952
ISSN:
19352735
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Case-Control Study