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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
D
2
P
2
: Database of disordered protein predictions
Nucleic Acids Research, Volume 41, No. D1, Year 2013
Notification
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Description
We present the Database of Disordered Protein Prediction (D 2P2), available at http://d2p2.pro (including website source code). A battery of disorder predictors and their variants, VL-XT, VSL2b, PrDOS, PV2, Espritz and IUPred, were run on all protein sequences from 1765 complete proteomes (to be updated as more genomes are completed). Integrated with these results are all of the predicted (mostly structured) SCOP domains using the SUPERFAMILY predictor. These disorder/structure annotations together enable comparison of the disorder predictors with each other and examination of the overlap between disordered predictions and SCOP domains on a large scale. D2P2 will increase our understanding of the interplay between disorder and structure, the genomic distribution of disorder, and its evolutionary history. The parsed data are made available in a unified format for download as flat files or SQL tables either by genome, by predictor, or for the complete set. An interactive website provides a graphical view of each protein annotated with the SCOP domains and disordered regions from all predictors overlaid (or shown as a consensus). There are statistics and tools for browsing and comparing genomes and their disorder within the context of their position on the tree of life. © The Author(s) 2012.
Authors & Co-Authors
Oates, Matt E.
United Kingdom, Bristol
University of Bristol
Romero, Pedro
United States, Indianapolis
Indiana University School of Medicine
Ishida, Takashi
Japan, Tokyo
Tokyo Institute of Technology
Ghalwash, Mohamed F.
United States, Philadelphia
Temple University
Egypt, Cairo
College of Science
Mizianty, Marcin J.
Canada, Edmonton
University of Alberta
Xue, Bin
United States, Tampa
University of South Florida, Tampa
Dosztányi, Zsuzsanna
Hungary, Budapest
Magyar Tudomanyos Akademia
Uversky, Vladimir N.
United States, Tampa
University of South Florida, Tampa
Russian Federation, Pushchino
Institute for Biological Instrumentation of Ras
Obradović, Zoran
United States, Philadelphia
Temple University
Kurgan, Lukasz A.
Canada, Edmonton
University of Alberta
Dunker, A. Keith
United States, Indianapolis
Indiana University School of Medicine
Gough, Julian
United Kingdom, Bristol
University of Bristol
Statistics
Citations: 572
Authors: 12
Affiliations: 9
Identifiers
Doi:
10.1093/nar/gks1226
ISSN:
03051048
e-ISSN:
13624962