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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Increased level of arginase activity correlates with disease severity in HIV-seropositive patients
Journal of Infectious Diseases, Volume 202, No. 3, Year 2010
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Description
Infection with human immunodeficiency virus (HIV) results in a chronic infection that progressively impairs the immune system. Although depletion of CD+ T cells is frequently used to explain immunosuppression, chronicity of infection and progressive loss of CD+ T cells are not sufficient to fully account for immune dysregulation. Arginase-induced L-arginine deprivation is emerging as a key mechanism for the down-regulation of immune responses. Here, we hypothesized that the level of arginase activity increases with disease severity in HIV-seropositive patients. We determined the levels of arginase activity in peripheral blood mononuclear cells from HIV-seropositive patients and uninfected control participants. Our results show that peripheral blood mononuclear cells from HIV-seropositive patients with low CD+ T cell counts expressed statistically significantly higher levels of arginase activity, compared with patients with high CD+ T cell counts or uninfected control participants. Furthermore, we found a statistically significant correlation between high level of arginase activity and high viral load in HIV-seropositive patients. © 2010 by the Infectious Diseases Society of America.
Authors & Co-Authors
Cloke, T. E.
Australia, Sydney
Faculty of Medicine
Garvey, Lucy J.
United Kingdom, London
Imperial College London
Choi, Beaksan
Australia, Sydney
Faculty of Medicine
Abebe, Tamrat Asfaw
Ethiopia, Addis Ababa
Addis Ababa University
Hailu, Asrat
Ethiopia, Addis Ababa
Addis Ababa University
Hancock, Margaret R.
United Kingdom, London
Charing Cross Hospital
Kadolsky, U.
Australia, Sydney
Faculty of Medicine
Bangham, Charles R.M.
Australia, Sydney
Faculty of Medicine
Munder, Markus
Germany, Heidelberg
Universität Heidelberg
Müller, Ingrid
Australia, Sydney
Faculty of Medicine
Taylor, Graham P.
United Kingdom, London
Imperial College London
Kropf, Pascale
Australia, Sydney
Faculty of Medicine
Statistics
Citations: 52
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1086/653736
ISSN:
00221899
Research Areas
Infectious Diseases