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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
HIV type 1 pol gene diversity and antiretroviral drug resistance mutations in the Democratic Republic of Congo (DRC)
AIDS Research and Human Retroviruses, Volume 22, No. 2, Year 2006
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Description
To study recombination and the natural polymorphism in pol of HIV-1 strains in the Democratic Republic of Congo (DRC) we sequenced the protease and RT genes for 70 HIV-1 strains previously characterized in the env V3-V5 region from a sentinel surveillance study in 2002. For 41 of the 70 (58.6%) strains, the same subtype/CRF designations were observed in pol and env. Twenty-three (32.9%) of 70 pol sequences were complex recombinants involving two to five subtypes as well as fragments that could not be classified into any of the known subtypes. All subtypes were involved in recombination events. Unclassified (U) and env subtype H strains were very likely to be recombinant strains. Overall, many minor mutations were identified in the protease sequences. Although at the time of our study ARV use was not yet widespread in DRC, three strains were identified with one major mutation associated with drug resistance: L90M and M46L in protease and K103N in RT. © Mary Ann Liebert, Inc.
Authors & Co-Authors
Vidal, Nicole
France, Montpellier
Ird Centre de Montpellier
Mulanga, Claire
France, Montpellier
Ird Centre de Montpellier
Bazepeo, Samuel Edidi
Congo
Laboratoire du Pnls
Mwamba, Jeanne Kasali
Congo
Laboratoire du Pnls
Tshimpaka, Jean Willy
Congo
Laboratoire du Pnls
Kashi, Mulowayi
Congo
Laboratoire de L'hôpital Dipumba
Mama, Nicaise
Congo
Laboratoire du Pnls
Valéa, Diane C.
France, Montpellier
Ird Centre de Montpellier
Delaporte, Éric
France, Montpellier
Ird Centre de Montpellier
Lepira, François Bompeka
Congo
Pnls
Peeters, Martine F.
France, Montpellier
Ird Centre de Montpellier
France, Marseille
Ird Institut de Recherche Pour le Developpement
Statistics
Citations: 51
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1089/aid.2006.22.202
ISSN:
08892229
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Locations
Congo