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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Tanzanian medicinal plants used traditionally for the treatment of malaria: In vivo antimalarial and in vitro cytotoxic activities
Phytotherapy Research, Volume 9, No. 7, Year 1995
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Description
Seventeen fractions of extracts obtained from 11 Tanzanian medicinal plants, which had previously been shown to possess a high antimalarial activity in vitro were submitted to the 4‐day suppressive test in Plasmodium berghei‐infected mice, and were investigated for cytotoxic activity in human carcinoma cell lines in vitro. Several fractions administered orally to the mice (500 mg/kg body weight/day) produced a significant reduction of parasitaemia. The most effective plant fractions investigated were those of the root and stem bark of Maytenus senegalensis (90% and 63% suppression of parasitaemia, respectively) and of the roots of Cissampelos mucronata (59% suppression). Highest cytotoxic activities were found with all fractions of Maytenus senegalensis (IC50 1 μg/mL) and with the PE fraction of the roots of Salacia madagascariensis (median IC50=1.2 μg/mL for HT 29 and 2.3 μg/mL for KB). Copyright © 1995 John Wiley & Sons, Ltd.
Authors & Co-Authors
Gessler, M. C.
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Tanner, Marcel
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Chollet, Jacques Y.
Switzerland, Basel
F. Hoffmann-la Roche ag
Nkunya, Mayunga H.H.
Tanzania, Dar es Salaam
University of Dar es Salaam
Heinrich, Michael M.
Germany, Freiburg Im Breisgau
Universität Freiburg
Statistics
Citations: 97
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1002/ptr.2650090708
ISSN:
0951418X
e-ISSN:
10991573
Research Areas
Cancer
Infectious Diseases