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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Targeting the Microbiome in Inflammatory Bowel Disease: Critical Evaluation of Current Concepts and Moving to New Horizons
Digestive Diseases, Volume 33, Year 2015
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Description
Microorganisms present in the intestine possess proinflammatory or anti-inflammatory activities which may modulate inflammatory bowel disease (IBD). The concepts followed by researchers in trying to target the microbiota in IBD were to decrease pathogens or pathobionts, or only the microbial load, and more recently, to favor growth and persistence of favorable microorganisms. We review, here, those concepts and critically analyze the clinical data (especially randomized controlled trials) obtained using antibiotics and probiotics. We eventually present and criticize the rational and data obtained so far following new research strategies including the use of new probiotics, genetically modified organisms and fecal transplantation. © 2015 S. Karger AG, Basel.
Authors & Co-Authors
Béjaoui, Mohamed
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Sokol, Harry
France, Paris
Hôpital Saint-antoine
Marteau, Philippe R.
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Statistics
Citations: 21
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1159/000437104
ISSN:
02572753