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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A single intravenous sTNFR-Fc administration at the time of reperfusion limits infarct size - Implications in reperfusion strategies in man
Cardiovascular Drugs and Therapy, Volume 22, No. 6, Year 2008
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Description
Background: Reperfusion of the ischemic myocardium is associated with increased inflammatory processes that can exert deleterious effects and therefore contribute to cardiac dysfunction. The aim of the present study was to verify whether the administration of sTNFR-Fc, a scavenger of the pro-inflammatory cytokine TNF-α, at the time of reperfusion would protect against myocardial infarction and reduce the severity of early mechanical dysfunction. Methods: Male Wistar rats were subjected to 60 min coronary occlusion followed by reperfusion. A bolus of sTNFR-Fc (10 μg/kg, i.v.) (MI + sTNFR-Fc group) or a placebo (MI group) was injected prior to reperfusion. Cardiac geometry was assessed by echocardiography 1, 3 and 7 days after reperfusion. Eight days after reperfusion, left ventricular (LV) function was evaluated under basal conditions and during an experimental challenge of volume overload. Finally, infarct size was measured after euthanasia. Results: sTNFR-Fc administration markedly reduced infarct size (P<0.01) and decreased LV dilation as assessed by the echocardiographic measurement of the LV end diastolic area, 7 days post-MI (P<0.01). Moreover, LV end-diastolic pressure was significantly preserved by sTNFR-Fc 1 week after myocardial infarction, under basal conditions (P<0.05) as well as during cardiac overload (P<0.05). Conclusion: A single administration of sTNFR-Fc at the time of reperfusion after myocardial infarction is able to limit infarct size and to reduce early LV diastolic dysfunction in rats. These findings suggest that intravenous neutralization of TNF-α during surgical cardiac reperfusion might improve the outcome of myocardial infarction in humans. © 2008 Springer Science+Business Media, LLC.
Authors & Co-Authors
Toufektsian, Marie Claire
France, La Tronche
Techniques for Biomedical Engineering and Complexity Management Informatics, Mathematics and Applications Grenoble Timc-imag
Robbez-Masson, Vanessa
France, La Tronche
Techniques for Biomedical Engineering and Complexity Management Informatics, Mathematics and Applications Grenoble Timc-imag
France, Gif-sur-yvette
Université Paris-saclay
Sanou, Drissa S.
Burkina Faso, Ouagadougou
University of Ouagadougou
Jouan, Marie Gabrielle
France, La Tronche
Techniques for Biomedical Engineering and Complexity Management Informatics, Mathematics and Applications Grenoble Timc-imag
Ormezzano, Olivier
France, La Tronche
Hôpital A. Michallon Chu Grenoble
de Leiris, Joël G.
France, La Tronche
Techniques for Biomedical Engineering and Complexity Management Informatics, Mathematics and Applications Grenoble Timc-imag
Boucher, François
France, La Tronche
Techniques for Biomedical Engineering and Complexity Management Informatics, Mathematics and Applications Grenoble Timc-imag
Statistics
Citations: 13
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1007/s10557-008-6130-y
ISSN:
09203206
Research Areas
Health System And Policy
Noncommunicable Diseases
Participants Gender
Male