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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Consensus statement on research definitions for drug-resistant tuberculosis in children
Journal of the Pediatric Infectious Diseases Society, Volume 2, No. 2, Article pit012, Year 2013
Notification
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Description
Few children with drug-resistant (DR) tuberculosis (TB) are identified, diagnosed, and given an appropriate treatment. The few studies that have described this vulnerable population have used inconsistent definitions. TheWorld Health Organization (WHO) definitions used for adults with DR-TB and for children with drug-susceptible TB are not always appropriate for children with DR-TB. The Sentinel Project on Pediatric Drug-Resistant Tuberculosis was formed in 2011 as a network of experts and stakeholders in childhood DRTB. An early priority was to establish standardized definitions for key parameters in order to facilitate study comparisons and the development of an evidence base to guide future clinical management. This consensus statement proposes standardized definitions to be used in research. In particular, it suggests consistent terminology, as well as definitions for measures of exposure, drug resistance testing, previous episodes and treatment, certainty of diagnosis, site and severity of disease, adverse events, and treatment outcome. © The Author 2013. Published by Oxford University Press on behalf of the Pediatric Infectious Diseases Society.
Authors & Co-Authors
Seddon, James Alexander
Unknown Affiliation
Pérez-Vélez, Carlos M.
Unknown Affiliation
Schaaf, Hendrik Simon
Unknown Affiliation
Furin, Jennifer Joan
Unknown Affiliation
Marais, Ben J.
Unknown Affiliation
Tebruegge, Marc O.
Unknown Affiliation
Detjen, Anne K.
Unknown Affiliation
Hesseling, Anneke Catharina
Unknown Affiliation
Shah, Sarita
Unknown Affiliation
Adams, Lisa V.
Unknown Affiliation
Starke, Jeffrey Robert
Unknown Affiliation
Swaminathan, Soumya
Unknown Affiliation
Becerra, Mercedes C.
Unknown Affiliation
Statistics
Citations: 48
Authors: 13
Affiliations: 17
Identifiers
Doi:
10.1093/jpids/pit012
ISSN:
20487193
e-ISSN:
20487207
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study