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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Exovesicles from human activated dendritic cells fuse with resting dendritic cells, allowing them to present alloantigens
American Journal of Pathology, Volume 169, No. 6, Year 2006
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Description
Dendritic cells (DCs) can release microvesicles, but the latter's numbers, size, and fate are unclear. Fluorescently labeled DCs were visualized by laser-scanning microscopy. Using a Surpass algorithm, we were able to identify and quantify per cell several hundred microvesicles released from the surface of stimulated DCs. We show that most of these microvesicles are not of endocytic origin but result from budding of the plasma membrane, hence their name, exovesicle. Using a double vital staining, we show that exovesicles isolated from activated DCs can fuse with the membrane of resting DCs, thereby allowing them to present alloantigens to lymphocytes. We concluded that, within a few hours from their release, exovesicles may amplify local or distant adaptive immunological response. Copyright © American Society for Investigative Pathology.
Authors & Co-Authors
Obregon, Carolina
Switzerland, Bern
University of Bern
Rothen-Rutishauser, Barbara M.
Switzerland, Bern
Institute of Anatomy
Gitahi, Stephen Kiama
Kenya, Nairobi
University of Nairobi
G’ehr, Peter
Switzerland, Bern
Institute of Anatomy
Nicod, Laurent Pierre
Switzerland, Bern
University of Bern
Switzerland, Bern
University Hospital Bern
Statistics
Citations: 117
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.2353/ajpath.2006.060453