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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Antibodies reacting with cytoplasm of subthalamic and caudate nuclei neurons in chorea and acute rheumatic fever*
Journal of Experimental Medicine, Volume 144, No. 4, Year 1976
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Description
46% of sera from 30 children with rheumatic chorea showed IgG antibody reacting with neuronal cytoplasm of human caudate and subthalamic nuclei. The antibody was also detected in 14% of 50 children with active rheumatic carditis. 55 normal control sera, as well as 148 sera from a broad variety of other disease states showed a low prevalence (1.8-4.0%) of positive reactions. In rheumatic chorea the presence of anti-neuronal antibody appeared to correlate with severity and duration of clinical attacks. Antibody reacting with neuronal cytoplasm was completely removed by absorption with Group A streptococcal membranes or with isolated human neurons from caudate nucleus. Partial absorption of antibody was also recorded using Group A cell wall preparations but not with Group A carbohydrate. No absorption of positive reactions was seen with streptococcal Group D membranes or cell walls. In rheumatic chorea, antineuronal antibody appeared to represent cross-reaction with antigens shared by Group A streptococcal membranes. © 1976, Rockefeller University Press., All rights reserved.
Authors & Co-Authors
Husby, Gunnar
United States, Albuquerque
Unm School of Medicine
Egypt, Cairo
Pyramid Rheumat. Heart Cent.
United States, New York
Rockefeller University
Van De Rijn, Ivo
United States, Albuquerque
Unm School of Medicine
Egypt, Cairo
Pyramid Rheumat. Heart Cent.
United States, New York
Rockefeller University
Zabriskie, John B.
United States, Albuquerque
Unm School of Medicine
Egypt, Cairo
Pyramid Rheumat. Heart Cent.
United States, New York
Rockefeller University
Abdin, Z. H.
United States, Albuquerque
Unm School of Medicine
Egypt, Cairo
Pyramid Rheumat. Heart Cent.
United States, New York
Rockefeller University
Williams, R. C.
United States, Albuquerque
Unm School of Medicine
Egypt, Cairo
Pyramid Rheumat. Heart Cent.
United States, New York
Rockefeller University
Statistics
Citations: 518
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1084/jem.144.4.1094
ISSN:
00221007
e-ISSN:
15409538
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study