Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Mitochondria function associated genes contribute to Parkinson’s Disease risk and later age at onset
npj Parkinson's Disease, Volume 5, No. 1, Article 8, Year 2019
Notification
URL copied to clipboard!
Description
Mitochondrial dysfunction has been implicated in the etiology of monogenic Parkinson’s disease (PD). Yet the role that mitochondrial processes play in the most common form of the disease; sporadic PD, is yet to be fully established. Here, we comprehensively assessed the role of mitochondrial function-associated genes in sporadic PD by leveraging improvements in the scale and analysis of PD GWAS data with recent advances in our understanding of the genetics of mitochondrial disease. We calculated a mitochondrial-specific polygenic risk score (PRS) and showed that cumulative small effect variants within both our primary and secondary gene lists are significantly associated with increased PD risk. We further reported that the PRS of the secondary mitochondrial gene list was significantly associated with later age at onset. Finally, to identify possible functional genomic associations we implemented Mendelian randomization, which showed that 14 of these mitochondrial function-associated genes showed functional consequence associated with PD risk. Further analysis suggested that the 14 identified genes are not only involved in mitophagy, but implicate new mitochondrial processes. Our data suggests that therapeutics targeting mitochondrial bioenergetics and proteostasis pathways distinct from mitophagy could be beneficial to treating the early stage of PD. © 2019, The Author(s).
Authors & Co-Authors
Billingsley, Kimberley J.
United Kingdom, Liverpool
University of Liverpool
United States, Bethesda
National Institutes of Health Nih
Barbosa, Inês A.M.
United Kingdom, London
King's College London
Bandres-Ciga, Sara
United States, Bethesda
National Institutes of Health Nih
Quinn, John P.
United Kingdom, Liverpool
University of Liverpool
Bubb, Vivien Jill
United Kingdom, Liverpool
University of Liverpool
Deshpande, Charu Mahesh
United Kingdom, London
Guy's and st Thomas' Nhs Foundation Trust
Botia, Juan A.
Spain, Murcia
Universidad de Murcia
United Kingdom, London
Ucl Queen Square Institute of Neurology
Reynolds, Regina Hertfelder
United Kingdom, London
Ucl Queen Square Institute of Neurology
Zhang, David
United Kingdom, London
Ucl Queen Square Institute of Neurology
Simpson, Michael A.
United Kingdom, London
King's College London
Blauwendraat, Cornelis
United States, Bethesda
National Institutes of Health Nih
Gan-Or, Ziv
Canada, Montreal
Université Mcgill
Gibbs, J. Raphael
United States, Bethesda
National Institutes of Health Nih
Nalls, Mike A.
United States, Bethesda
National Institutes of Health Nih
United States, Glen Echo
Data Tecnica International
Singleton, Andrew B.
United States, Bethesda
National Institutes of Health Nih
Noyce, Alastair John
United Kingdom, London
Queen Mary University of London
Tucci, Arianna
United Kingdom, London
Ucl Queen Square Institute of Neurology
Middlehurst, Ben
United Kingdom, Liverpool
University of Liverpool
Kia, Demis A.
United Kingdom, London
University College London
Tan, Manuela M.X.
United Kingdom, London
University College London
Houlden, Henry H.
United Kingdom, London
Ucl Queen Square Institute of Neurology
Morris, Huw R.
United Kingdom, London
University College London
Plun-Favreau, Hélène
United Kingdom, London
Ucl Queen Square Institute of Neurology
Holmans, Peter A.
United Kingdom, Cardiff
Mrc Centre for Neuropsychiatric Genetics and Genomics
Hardy, John A.
United Kingdom, London
Ucl Queen Square Institute of Neurology
Trabzuni, Daniah
United Kingdom, London
Ucl Queen Square Institute of Neurology
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Brás, José Miguel
United Kingdom, London
University College London
Mok, Kin Y.
United Kingdom, London
Ucl Queen Square Institute of Neurology
Kinghorn, Kerri J.
United Kingdom, London
University College London
Wood, Nick William
United Kingdom, London
University College London
Lewis, Patrick A.
United Kingdom, Reading
University of Reading
Guerreiro, Rita João
United Kingdom, London
Ucl Queen Square Institute of Neurology
United Kingdom, London
University College London
Lovering, Ruth C.
United Kingdom, London
University College London
R’Bibo, Lea
United Kingdom, London
Ucl Queen Square Institute of Neurology
Rizig, Mie A.
United Kingdom, London
Ucl Queen Square Institute of Neurology
Escott-Price, Valentina
United Kingdom, Cardiff
Mrc Centre for Neuropsychiatric Genetics and Genomics
United Kingdom, Cardiff
Cardiff University School of Medicine
Chelban, Viorica
United Kingdom, London
Ucl Queen Square Institute of Neurology
Foltynie, Thomas
United Kingdom, London
Ucl Queen Square Institute of Neurology
Williams, Nigel M.
United Kingdom, Cardiff
Cardiff University School of Medicine
Brice, Alexis
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Danjou, Fabrice
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Lesage, Suzanne
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Martinez, Maria M.
France, Paris
Cnrs Centre National de la Recherche Scientifique
Giri, Anamika
Germany, Tubingen
Eberhard Karls Universität Tübingen
Germany, Bonn
Deutsches Zentrum Für Neurodegenerative Erkrankungen
Schulte, Claudia M.S.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Germany, Bonn
Deutsches Zentrum Für Neurodegenerative Erkrankungen
Brockmann, Kathrin
Germany, Tubingen
Eberhard Karls Universität Tübingen
Germany, Bonn
Deutsches Zentrum Für Neurodegenerative Erkrankungen
Simón-Sánchez, Javier
Germany, Tubingen
Eberhard Karls Universität Tübingen
Germany, Bonn
Deutsches Zentrum Für Neurodegenerative Erkrankungen
Heutink, Peter
Germany, Tubingen
Eberhard Karls Universität Tübingen
Germany, Bonn
Deutsches Zentrum Für Neurodegenerative Erkrankungen
Rizzu, Patrizia
Germany, Bonn
Deutsches Zentrum Für Neurodegenerative Erkrankungen
Sharma, Manu
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gasser, Thomas
Germany, Tubingen
Eberhard Karls Universität Tübingen
Germany, Bonn
Deutsches Zentrum Für Neurodegenerative Erkrankungen
Nicolas, Aude
United States, Bethesda
National Institutes of Health Nih
Cookson, Mark Robert
United States, Bethesda
National Institutes of Health Nih
Faghri, Faraz
United States, Bethesda
National Institutes of Health Nih
United States, Urbana
University of Illinois Urbana-champaign
Hernandez, Dena G.
United States, Bethesda
National Institutes of Health Nih
Shulman, Joshua M.
United States, Houston
Baylor College of Medicine
United States, Houston
Texas Children's Hospital
Robak, Laurie A.
United States, Houston
Baylor College of Medicine
Lubbe, Steven J.
United States, Chicago
Northwestern University Feinberg School of Medicine
Finkbeiner, Steven M.
United States, San Francisco
University of California, San Francisco
United States, San Francisco
Gladstone Institute of Neurological Disease
United States, San Francisco
Taube/koret Center for Neurodegenerative Disease Research
Mencacci, Niccolò Emanuele
United States, Chicago
Northwestern University Feinberg School of Medicine
Lungu, Codrin I.
United States, Bethesda
National Institutes of Health Nih
Scholz, Sonja W.
United States, Bethesda
National Institute of Neurological Disorders and Stroke
Reed, Xylena
United States, Bethesda
National Institutes of Health Nih
Leonard, Hampton L.
United States, Bethesda
National Institutes of Health Nih
Rouleau, Guy Armand
Canada, Montreal
Université Mcgill
Krohan, Lynne
Canada, Montreal
Université Mcgill
van Hilten, Jacobus Johannes Bob
Netherlands, Leiden
Leids Universitair Medisch Centrum
Marinus, Johan
Netherlands, Leiden
Leids Universitair Medisch Centrum
Adarmes-GɃmez, Astrid D.
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Aguilar, Miquel Chávez
Spain, Terrassa
Mutua de Terrassa
Alvarez, Ignacio
Spain, Terrassa
Mutua de Terrassa
Álvarez, Victoria M.P.
Spain, Oviedo
Hospital Universitario Central de Asturias
Javier Barrero, F.
Spain, Granada
Hospital Universitario Parque Tecnológico de la Salud
Bergareche Yarza, Jesús Alberto
Spain, Donostia-san Sebastian
Biodonostia Health Research Institute
Bernal-Bernal, Inmaculada
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Blázquez Estrada, Marta
Spain, Oviedo
Hospital Universitario Central de Asturias
Bernal, Maria Bonilla Toribio
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Boungiorno, María Teresa
Spain, Terrassa
Mutua de Terrassa
Buiza-Rueda, Dolores
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Cámara, Ana
Spain, Barcelona
Hospital Clinic Barcelona
Cárcel, María
Spain, Terrassa
Mutua de Terrassa
Carrillo, Fátima
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Carrion-Claro, Mario
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Cerdán, Débora María
Spain, Segovia
Hospital General de Segovia
Clarimón, Jordi
Spain, Barcelona
Institut de Recerca Sant Pau ir Sant Pau
Spain, Madrid
Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas
Compta, Yaroslau
Spain, Barcelona
Hospital Clinic Barcelona
Diez-Fairen, Monica
Spain, Terrassa
Mutua de Terrassa
Dols-Icardo, Oriol
Spain, Barcelona
Institut de Recerca Sant Pau ir Sant Pau
Spain, Madrid
Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas
Duarte, Jacinto
Spain, Segovia
Hospital General de Segovia
Duran, R. L.
Spain, Granada
Universidad de Granada
Escamilla, Francisco
Spain, Granada
Complejo Hospitalario Universitario de Granada
Ezquerra, Mario
Spain, Barcelona
Hospital Clinic Barcelona
Fernández-Martínez, Manuel Jesús
Spain, Barcelona
Hospital Clinic Barcelona
Fernández-Santiago, Rubén
Spain, Barcelona
Hospital Clinic Barcelona
Garcia, Ciara
Spain, Oviedo
Hospital Universitario Central de Asturias
García-Ruiz, Pedro J.
Spain, Madrid
Hospital Universitario Fundación Jiménez Díaz
Gómez-Garre, Pilar
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Heredia, María José Gómez
Spain, Malaga
Hospital Universitari Virgen de la Victoria
González-Aramburu, Isabel
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Pagola, Ana Gorostidi
Spain, Donostia-san Sebastian
Biodonostia Health Research Institute
Infante-Ceberio, Jon
Spain, Madrid
Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Jesús, Silvia
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Labrador-Espinosa, Miguel A.
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
de Munain Arregui, Adolfo López
Spain, Madrid
Hospital Universitario Ramón y Cajal
Macías, Daniel
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Martí, María José
Spain, Barcelona
Hospital Clinic Barcelona
Méndez-Del-Barrio, Carlota
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Menéndez-González, Manuel
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Mir, Pablo
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Rezola, Elisabet Mondragón
Spain, Donostia-san Sebastian
Biodonostia Health Research Institute
Pástor, Pau
Spain, Terrassa
Mutua de Terrassa
Periñan, Maria Teresa
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Ruíz-Martínez, Javier
Spain, Donostia-san Sebastian
Biodonostia Health Research Institute
Suarez-Sanmartin, Esther
United Kingdom, London
Guy's and st Thomas' Nhs Foundation Trust
Tartari, Juan Pablo
Spain, Terrassa
Mutua de Terrassa
Tejera-Parrado, Cristina
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Tolosa, Eduardo S.
Spain, Barcelona
Hospital Clinic Barcelona
Vargas-González, Laura
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Vives, F.
Spain, Granada
Universidad de Granada
Zimprich, Alexander
Austria, Vienna
Medizinische Universität Wien
Pihlstrom, Lasse
Norway, Oslo
Oslo Universitetssykehus
Taba, Pille
Estonia, Tartu
Tartu Ülikool
Okubadejo, Njideka U.
Nigeria, Lagos
University of Lagos
Ojo, Oluwadamilola Omolara
Nigeria, Lagos
University of Lagos
Ryten, Mina
United Kingdom, London
Ucl Queen Square Institute of Neurology
Kõks, Sulev V.
Australia, Perth
Perron Institute for Neurological and Translational Science
Australia, Perth
Murdoch University
Statistics
Citations: 99
Authors: 126
Affiliations: 53
Identifiers
Doi:
10.1038/s41531-019-0080-x
ISSN:
23738057
Research Areas
Genetics And Genomics
Study Design
Randomised Control Trial