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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children
Blood, Volume 119, No. 8, Year 2012
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Description
Iron supplementation strategies in the developing world remain controversial because of fears of exacerbating prevalent infectious diseases. Understanding the conditions in which iron will be absorbed and incorporated into erythrocytes is therefore important. We studied Gambian children with either postmalarial or nonmalarial anemia, who were given oral iron supplements daily for 30 days. Supplements administered on days 1 and 15 contained the stable iron isotopes 57Fe and 58Fe, respectively, and erythrocyte incorporation was measured in blood samples drawn 14 days later. We investigated how the iron-regulatory hormone hepcidin and other inflammatory/ironrelated indices, all measured on the day of isotope administration, correlated with erythrocyte iron incorporation. In univariate analyses, hepcidin, ferritin, C-reactive protein, and soluble transferrin receptor (sTfR) strongly predicted incorporation of 57Fe given on day 1, while hepcidin, ferritin, and sTfR/log ferritin correlated with 58Fe incorporation. In a final multivariate model, the most consistent predictor of erythrocyte isotope incorporation was hepcidin. We conclude that under conditions of competing signals (anemia, iron deficiency, and infection), hepcidin powerfully controls use of dietary iron. We suggest that low-cost point-of-care hepcidin assays would aid iron supplementation programs in the developing world. © 2012 by The American Society of Hematology.
Authors & Co-Authors
Prentice, Andrew M.
Unknown Affiliation
Doherty, Conor
Unknown Affiliation
Abrams, Steven A.
Unknown Affiliation
Cox, Sharon E.
Unknown Affiliation
Atkinson, Sarah H.
Unknown Affiliation
Verhoef, Hans
Unknown Affiliation
Armitage, Andrew E.
Unknown Affiliation
Drakesmith, Hal H.
Unknown Affiliation
Statistics
Citations: 178
Authors: 8
Affiliations: 7
Identifiers
Doi:
10.1182/blood-2011-11-391219
ISSN:
00064971
Research Areas
Health System And Policy
Maternal And Child Health