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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Characteristics of Plasmodium falciparum dhfr haplotypes that confer pyrimethamine resistance, Kilifi, Kenya, 1987-2006
Journal of Infectious Diseases, Volume 197, No. 12, Year 2008
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Description
Resistance to the antimalarial drug sulfadoxine-pyrimethamine (SP) emerged in Plasmodium falciparum from Asia in the 1960s and subsequently spread to Africa. It is not known whether alleles that confer SP resistance also arose independently in Africa. We defined the coding region and microsatellite haplotypes of dhfr alleles in P. falciparum collected in Kilifi, Kenya, during 1987-2006, which spans the period when SP was first introduced. Isolates that carried a double-mutant or triple-mutant dhfr allele were detected at a low frequency, even during 1987-1988. Each of 2 double mutants carried a unique haplotype, and both were related to wild-type haplotypes from the same population. The number of isolates that carried a triple-mutant dhfr allele increased rapidly after introduction of SP and shared the haplotype of the triple mutant derived form Asia.Weobserved no triple-mutant alleles with haplotypes related to those of the Africa-derived wild-type and double-mutant alleles. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Certain, Laura
United States, Seattle
University of Washington
Briceño, Marnie
United States, Seattle
University of Washington
Kiara, Steven M.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Nzila, Alexis M.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Watkins, Williams M.
United Kingdom, Oxford
Nuffield Department of Medicine
Sibley, Carol Hopkins
United States, Seattle
University of Washington
Statistics
Citations: 44
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1086/588198
ISSN:
00221899
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Kenya