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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Discovery and characterization of distinct simian pegiviruses in three wild African old world monkey species
PLoS ONE, Volume 9, No. 6, Article e98569, Year 2014
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Description
Within the Flaviviridae, the recently designated genus Pegivirus has expanded greatly due to new discoveries in bats, horses, and rodents. Here we report the discovery and characterization of three simian pegiviruses (SPgV) that resemble human pegivirus (HPgV) and infect red colobus monkeys (Procolobus tephrosceles), red-tailed guenons (Cercopithecus ascanius) and an olive baboon (Papio anubis). We have designated these viruses SPgVkrc, SPgV krtg and SPgVkbab, reflecting their host species' common names, which include reference to their location of origin in Kibale National Park, Uganda. SPgVkrc and SPgVkrtg were detected in 47% (28/60) of red colobus and 42% (5/12) red-tailed guenons, respectively, while SPgVkbab infection was observed in 1 of 23 olive baboons tested. Infections were not associated with any apparent disease, despite the generally high viral loads observed for each variant. These viruses were monophyletic and equally divergent from HPgV and pegiviruses previously identified in chimpanzees (SPgVcpz). Overall, the high degree of conservation of genetic features among the novel SPgVs, HPgV and SPgVcpz suggests conservation of function among these closely related viruses. Our study describes the first primate pegiviruses detected in Old World monkeys, expanding the known genetic diversity and host range of pegiviruses and providing insight into the natural history of this genus. © 2014 Sibley et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4053331/bin/pone.0098569.s001.eps
https://efashare.b-cdn.net/share/pmc/articles/PMC4053331/bin/pone.0098569.s002.eps
https://efashare.b-cdn.net/share/pmc/articles/PMC4053331/bin/pone.0098569.s003.eps
https://efashare.b-cdn.net/share/pmc/articles/PMC4053331/bin/pone.0098569.s004.eps
https://efashare.b-cdn.net/share/pmc/articles/PMC4053331/bin/pone.0098569.s005.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC4053331/bin/pone.0098569.s006.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC4053331/bin/pone.0098569.s007.pdf
Authors & Co-Authors
Sibley, Samuel D.
United States, Madison
University of Wisconsin-madison
Lauck, Michael
United States, Madison
University of Wisconsin-madison
Bailey, Adam L.
United States, Madison
University of Wisconsin-madison
Hyeroba, David
Uganda, Kampala
Makerere University
Tumukunde, Alex
Uganda, Kampala
Makerere University
Weny, Geoffrey
Uganda, Kampala
Makerere University
Chapman, Colin A.
Uganda, Kampala
Makerere University
Canada, Sainte-anne-de-bellevue
Mcgill University, Macdonald Campus
O'Connor, David H.
United States, Madison
University of Wisconsin-madison
United States, Madison
Wisconsin National Primate Research Center
Goldberg, Tony L.
United States, Madison
University of Wisconsin-madison
Uganda, Kampala
Makerere University
United States, Madison
Wisconsin National Primate Research Center
Friedrich, Thomas C.
United States, Madison
University of Wisconsin-madison
United States, Madison
Wisconsin National Primate Research Center
Statistics
Citations: 48
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pone.0098569
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Study Locations
Uganda