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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
DDESC: Dragon database for exploration of sodium channels in human
BMC Genomics, Volume 9, No. SUPPL. 2, Article 622, Year 2008
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Description
Background: Sodium channels are heteromultimeric, integral membrane proteins that belong to a superfamily of ion channels. The mutations in genes encoding for sodium channel proteins have been linked with several inherited genetic disorders such as febrile epilepsy, Brugada syndrome, ventricular fibrillation, long QT syndrome, or channelopathy associated insensitivity to pain. In spite of these significant effects that sodium channel proteins/genes could have on human health, there is no publicly available resource focused on sodium channels that would support exploration of the sodium channel related information. Results: We report here Dragon Database for Exploration of Sodium Channels in Human (DDESC), which provides comprehensive information related to sodium channels regarding different entities, such as "genes and proteins", "metabolites and enzymes", "toxins", "chemicals with pharmacological effects", "disease concepts", "human anatomy", "pathways and pathway reactions" and their potential links. DDESC is compiled based on text- and data-mining. It allows users to explore potential associations between different entities related to sodium channels in human, as well as to automatically generate novel hypotheses. Conclusion: DDESC is first publicly available resource where the information related to sodium channels in human can be explored at different levels. This database is freely accessible for academic and non-profit users via the worldwide web http://apps.sanbi.ac.za/ddesc. © 2008 Sagar et al; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2631582/bin/1471-2164-9-622-S1.doc
Authors & Co-Authors
Sagar, Sunil
South Africa, Bellville
University of the Western Cape
Kaur, Mandeep
South Africa, Bellville
University of the Western Cape
Dawe, Adam S.
South Africa, Bellville
University of the Western Cape
Seshadri, Sundararajan V.
South Africa, Bellville
University of the Western Cape
Christoffels, Alan G.
South Africa, Bellville
University of the Western Cape
Schaefer, Ulf
South Africa, Bellville
University of the Western Cape
Radovanovic, Aleksandar
South Africa, Bellville
University of the Western Cape
Bajic, Vladimir B.
South Africa, Bellville
University of the Western Cape
Statistics
Citations: 20
Authors: 8
Affiliations: 1
Identifiers
Doi:
10.1186/1471-2164-9-622
e-ISSN:
14712164
Research Areas
Environmental
Genetics And Genomics