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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Microbiology of Urinary Tract Infections in Gaborone, Botswana
PLoS ONE, Volume 8, No. 3, Article e57776, Year 2013
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Description
Objective: The microbiology and epidemiology of UTI pathogens are largely unknown in Botswana, a high prevalence HIV setting. Using laboratory data from the largest referral hospital and a private hospital, we describe the major pathogens causing UTI and their antimicrobial resistance patterns. Methods: This retrospective study examined antimicrobial susceptibility data for urine samples collected at Princess Marina Hospital (PMH), Bokamoso Private Hospital (BPH), or one of their affiliated outpatient clinics. A urine sample was included in our dataset if it demonstrated pure growth of a single organism and accompanying antimicrobial susceptibility and subject demographic data were available. Results: A total of 744 samples were included. Greater than 10% resistance was observed for amoxicillin, co-trimoxazole, amoxicillin-clavulanate, and ciprofloxacin. Resistance of E. coli isolates to ampicillin and co-trimoxazole was greater than 60% in all settings. HIV status did not significantly impact the microbiology of UTIs, but did impact antimicrobial resistance to co-trimoxazole. Conclusions: Data suggests that antimicrobial resistance has already emerged to most oral antibiotics, making empiric management of outpatient UTIs challenging. Ampicillin, co-trimoxazole, and ciprofloxacin should not be used as empiric treatment for UTI in this context. Nitrofurantoin could be used for simple cystitis; aminoglycosides for uncomplicated UTI in inpatients. © 2013 Renuart et al.
Authors & Co-Authors
Renuart, Andrew J.
United States, Philadelphia
Botswana-upenn Partnership
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Goldfarb, David M.
United States, Philadelphia
Botswana-upenn Partnership
Canada, Hamilton
Mcmaster University
Botswana, Gaborone
University of Botswana
Mokomane, Margaret
Botswana, Gaborone
National Health Laboratory
Tawanana, Ephraim O.
Botswana, Gaborone
Princess Marina Hospital
Narasimhamurthy, Mohan
Botswana, Gaborone
Bokamoso Private Hospital
Steenhoff, Andrew P.
United States, Philadelphia
Botswana-upenn Partnership
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Botswana, Gaborone
University of Botswana
United States, Philadelphia
The Children's Hospital of Philadelphia
Silverman, Jonathan A.
Botswana, Gaborone
University of Botswana
United States, Seattle
University of Washington School of Medicine
Statistics
Citations: 26
Authors: 7
Affiliations: 9
Identifiers
Doi:
10.1371/journal.pone.0057776
e-ISSN:
19326203
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Botswana