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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
New and bioactive sesquiterpenes from Schisandra sphenanthera
Helvetica Chimica Acta, Volume 94, No. 12, Year 2011
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Description
Three new sesquiterpenes, schisansphenins A (1) and B (2) and (-)-γ-cuparenol (3), were isolated from an acetone extract of the fruits of Schisandra sphenanthera. The known compound 4 was isolated for the frist time from a natural source. The structures of the isolated compounds were elucidated through extensive spectroscopic analyses, particularly 2D-NMR experiments ( 1H, 1H-COSY, HMQC, HMBC, and NOESY). A plausible biogenetic pathway for schisansphenin B (2) is proposed. Compounds 2 and 3 significantly reduced activation of NF-AT and NF-κB in the luciferase-reporter assay. Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich, Switzerland.
Authors & Co-Authors
Lo, Iiwen
Taiwan, Taipei
National Taiwan University
Fazary, Ahmed E.
Taiwan, Taipei
National Taiwan University
Shen, Yaching
Taiwan, Taipei
National Taiwan University
Statistics
Citations: 10
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1002/hlca.201100205
ISSN:
15222675