Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Association analysis of HLA-Class II and Class III gene polymorphisms in the susceptibility to mediterranean visceral leishmaniasis
Human Immunology, Volume 62, No. 5, Year 2001
Notification
URL copied to clipboard!
Description
HLA-DRB1, -DQB1, TNFα, TNFβ, HSP70-2 and HSP70-hom genetic polymorphisms were analyzed in 156 unrelated patients who developed mediterranean visceral leishmaniasis (MVL) due to Leishmania infantum, and 154 unrelated healthy controls, who have got asymptomatic infection with this parasite and were selected on the basis of a positive leishmanin skin test (LST). A significantly reduced frequency of HLA-DR2 was observed among MVL patients (16.1%), compared with controls (26.3%) (relative risk = 0.54; p = 0.04). HLA-DR2/DR13 as well as HLA-DQB1*0201/- genotype frequencies were significantly lower in patients vs controls (relapse rate = 0.17 and 0.46, respectively; p < 0.05). However, using Bonferroni correction, none of these associations remained significant. No association was found, between either the -308 base pair TNFα gene polymorphism or the NcoI polymorphism in the first intron of the TNFβ gene and susceptibility to MVL. Analysis of PstI and NcoI polymorphisms in the coding region of HSP70-2 and HSP70-hom genes, respectively, revealed a significantly higher frequency of homozygotes for the HSP70-2/PstI negative allele, among patients (21.8%) vs controls (12.6%) (relapse rate = 1.94; p = 0.04). Again, this result was not significant after using Bonferroni correction. These results do not support association between susceptibility to MVL and the MHC class II and class III loci analyzed in this study. © American Society for Histocompatibility and Immunogenetics, 2001. Published by Elsevier Science Inc.
Authors & Co-Authors
Meddeb-Garnaoui, Amel
Tunisia, Tunis
Lab. Immunol.
Gritli, Sami
Tunisia, Tunis
Lab. Immunol.
Garbouj, S.
Tunisia, Tunis
Lab. Immunol.
Ben Fadhel, M.
Tunisia, Tunis
Lab. Immunol.
El Kares, R.
Tunisia, Tunis
Lab. Immunol.
Mansour, Lamjed
Tunisia, Tunis
Lab. Immunol.
Kâabi, Belhassen
Tunisia, Tunis
Lab. Immunol.
United States, Cleveland
Case Western Reserve University
Chouchane, Lotfi
Tunisia, Monastir
Faculté de Médecine de Monastir
Ben Salah, Afif A.
Tunisia, Tunis
Institut Pasteur de Tunis
Dellagi, Koussey
Tunisia, Tunis
Lab. Immunol.
Statistics
Citations: 51
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1016/S0198-8859(01)00237-3
ISSN:
01988859
Research Areas
Genetics And Genomics