Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Association between plasma triglycerides and high-density lipoprotein cholesterol and microvascular kidney disease and retinopathy in type 2 diabetes mellitus: A global case-control study in 13 countries
Circulation, Volume 129, No. 9, Year 2014
Notification
URL copied to clipboard!
Description
BACKGROUND-: Microvascular renal and retinal diseases are common major complications of type 2 diabetes mellitus. The relation between plasma lipids and microvascular disease is not well established. METHODS AND RESULTS-: The case subjects were 2535 patients with type 2 diabetes mellitus with an average duration of 14 years, 1891 of whom had kidney disease and 1218 with retinopathy. The case subjects were matched for diabetes mellitus duration, age, sex, and low-density lipoprotein cholesterol to 3683 control subjects with type 2 diabetes mellitus who did not have kidney disease or retinopathy. The study was conducted in 24 sites in 13 countries. The primary analysis included kidney disease and retinopathy cases. Matched analysis was performed by use of site-specific conditional logistic regression in multivariable models that adjusted for hemoglobin A1c, hypertension, and statin treatment. Mean low-density lipoprotein cholesterol concentration was 2.3 mmol/L. The microvascular disease odds ratio increased by a factor of 1.16 (95% confidence interval, 1.11-1.22) for every 0.5 mmol/L (≈1 quintile) increase in triglycerides or decreased by a factor of 0.92 (0.88-0.96) for every 0.2 mmol/L (≈1 quintile) increase in high-density lipoprotein cholesterol. For kidney disease, the odds ratio increased by 1.23 (1.16-1.31) with triglycerides and decreased by 0.86 (0.82-0.91) with high-density lipoprotein cholesterol. Retinopathy was associated with triglycerides and high-density lipoprotein cholesterol in matched analysis but not significantly after additional adjustment. CONCLUSIONS-: Diabetic kidney disease is associated worldwide with higher levels of plasma triglycerides and lower levels of high-density lipoprotein cholesterol among patients with good control of low-density lipoprotein cholesterol. Retinopathy was less robustly associated with these lipids. These results strengthen the rationale for studying dyslipidemia treatment to prevent diabetic microvascular disease. © 2014 American Heart Association, Inc.
Authors & Co-Authors
Sacks, Frank M.
United States, Boston
Harvard T.h. Chan School of Public Health
Hermans, Michel Paul
Belgium, Brussels
Cliniques Universitaires Saint-luc
Fioretto, Paola
Italy, Padua
Università Degli Studi Di Padova
Valensi, Paul Elie
France, Villetaneuse
University Sorbonne Paris Nord
Davis, Timothy M.E.
Australia, Perth
The University of Western Australia
Horton, Edward S.
United States, Boston
Joslin Diabetes Center
Wanner, Christoph
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Al-Rubeaan, Khalid A.
Saudi Arabia, Riyadh
College of Medicine
Aronson, Ronnie S.
Canada, Toronto
Lmc Healthcare
Barzon, Isabella
Italy, Padua
Università Degli Studi Di Padova
Bishop, Louise M.
Belgium, Brussels
Cliniques Universitaires Saint-luc
Bonora, Enzo
Italy, Verona
Università Di Verona Scuola Di Medicina e Chirurgia
Bunnag, Pongamorn
Thailand, Bangkok
Ramathibodi Hospital
Chuang, Lee Ming
Taiwan, Taipei
National Taiwan University Hospital
Deerochanawong, Chaicharn
Thailand, Bangkok
Rajavithi Hospital
Goldenberg, Ronald M.
Canada, Toronto
North York General Hospital
Harshfield, Benjamin J.
United States, Boston
Brigham and Women's Hospital
Hernández, Cristina S.
Spain, Madrid
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas
Herzlinger-Botein, Susan
United States, Boston
Joslin Diabetes Center
Itoh, Hiroshi
Japan, Tokyo
Keio University
Jia, Weiping
China, Shanghai
Shanghai Jiao Tong University
Jiang, Yi-Der Der
Taiwan, Taipei
National Taiwan University Hospital
Kadowaki, Takahashi
Japan, Tokyo
The University of Tokyo
Laranjo, Nancy M.
United States, Boston
Brigham and Women's Hospital
Leiter, Lawrence Alan
Canada, Toronto
University of Toronto
Miwa, Takashi
Japan, Tokyo
Keio University
Odawara, Masato
Japan, Tokyo
Tokyo Medical University
Ohashi, Ken
Japan, Tokyo
National Cancer Center Hospital
Ohno, Atsushi
Japan, Tokyo
Tokyo Medical University
Pan, Changyu
China, Beijing
Beijing 301 Military General Hospital
Pan, Jiemin
China, Shanghai
Shanghai Jiao Tong University
Pedro-Botet, Juan Carlos
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Reiner, Željko
Croatia, Zagreb
Kbc Zagreb
Rotella, Carlo Maria
Italy, Florence
Università Degli Studi Di Firenze
Simó, Rafael
Spain, Madrid
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas
Tanaka, Masami
Japan, Tokyo
Tokyo Medical University
Tedeschi-Reiner, Eugenia
Croatia, Zagreb
Klinički Bolnički Centar Sestre Milosrdnice
Twum-Barima, David Yaw
Canada, Toronto
Lmc Healthcare
Zoppini, Giacomo
Italy, Verona
Università Di Verona Scuola Di Medicina e Chirurgia
Carey, Vincent J.
United States, Boston
Brigham and Women's Hospital
Statistics
Citations: 40
Authors: 40
Affiliations: 27
Identifiers
Doi:
10.1161/CIRCULATIONAHA.113.002529
ISSN:
00097322
e-ISSN:
15244539
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Case-Control Study