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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Global dispersal pattern of HIV type 1 subtype CRF01-AE: A genetic trace of human mobility related to heterosexual sexual activities centralized in southeast Asia
Journal of Infectious Diseases, Volume 211, No. 11, Year 2015
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Description
Background. Human immunodeficiency virus type 1 (HIV-1) subtype CRF01-AE originated in Africa and then passed to Thailand, where it established a major epidemic. Despite the global presence of CRF01-AE, little is known about its subsequent dispersal pattern. Methods. We assembled a global data set of 2736 CRF01-AE sequences by pooling sequences from public databases and patient-cohort studies. We estimated viral dispersal patterns, using statistical phylogeographic analysis run over bootstrap trees estimated by the maximum likelihood method. Results. We show that Thailand has been the source of viral dispersal to most areas worldwide, including 17 of 20 sampled countries in Europe. Japan, Singapore, Vietnam, and other Asian countries have played a secondary role in the viral dissemination. In contrast, China and Taiwan have mainly imported strains from neighboring Asian countries, North America, and Africa without any significant viral exportation. Discussion. The central role of Thailand in the global spread of CRF01-AE can be probably explained by the popularity of Thailand as a vacation destination characterized by sex tourism and by Thai emigration to the Western world. Our study highlights the unique case of CRF01-AE, the only globally distributed non-B clade whose global dispersal did not originate in Africa. © 2014 The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Angelis, Konstantinos
Greece, Athens
National and Kapodistrian University of Athens
Albert, Jan
Sweden, Stockholm
Karolinska Universitetssjukhuset
Mamais, Ioannis A.
Greece, Athens
National and Kapodistrian University of Athens
Hatzakis, Angelos E.
Greece, Athens
National and Kapodistrian University of Athens
Hamouda, Osamah
Germany, Berlin
Robert Koch Institute
Struck, Daniel
Luxembourg, Strassen
Luxembourg Institute of Health
Vercauteren, Jurgen
Belgium, Leuven
Rega Institute for Medical Research
Wensing, Annemarie Marie J.
Netherlands, Utrecht
University Medical Center Utrecht
Alexiev, Ivailo
Bulgaria, Sofia
National Center of Infectious and Parasitic Diseases Bulgaria
Åsjö, Birgitta
Norway, Bergen
Universitetet I Bergen
Balotta, Claudia
Italy, Milan
Università Degli Studi Di Milano
Camacho, Ricardo Jorge
Portugal, Lisbon
Universidade Nova de Lisboa
Grossman, Zehava
Israel, Tel Aviv-yafo
Tel Aviv University
Horban, Andrzéj
Poland, Warsaw
Sp Zoz Wojewódzki Szpital Zakazny - Centrum Diagnostyki I Terapii Aids, Warszawa
Kostrikis, Leontios G.
Cyprus, Nicosia
University of Cyprus
Zidovec Lepej, Snjezana
Croatia, Zagreb
University Hospital for Infectious Diseases dr Fran Mihaljevic
Liitsola, Kirsi
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Linka, Marek
United States, Bethesda
National Institutes of Health Nih
Nielsen, Claus M.
Denmark, Copenhagen
Statens Serum Institut
Oţelea, Dan
Unknown Affiliation
Paredes, Roger
Unknown Affiliation
Poljak, Mario
Slovenia, Ljubljana
Univerza V Ljubljani
Puchhammer-Stöckl, Elisabeth
Sweden, Stockholm
Karolinska Universitetssjukhuset
Sweden, Stockholm
Karolinska Institutet
Schmit, Jean Claude
Luxembourg, Strassen
Luxembourg Institute of Health
Sönnerborg, Anders B.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Sweden, Stockholm
Karolinska Institutet
Stanojevic, Maja
Serbia, Belgrade
University of Belgrade
Boucher, Charles A.B.
Netherlands, Rotterdam
Erasmus Mc
Kaplan, Lauren M.
United States, Emeryville
Alcohol Research Group
Vandamme, Anne Mieke
Belgium, Leuven
Rega Institute for Medical Research
Portugal, Lisbon
Universidade Nova de Lisboa
Paraskevis, D. N.
Greece, Athens
National and Kapodistrian University of Athens
Statistics
Citations: 62
Authors: 30
Affiliations: 25
Identifiers
Doi:
10.1093/infdis/jiu666
ISSN:
00221899
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cohort Study