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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cardioprotective effect of VEGF and venom VEGF-like protein in acute myocardial ischemia in mice: Effect on mitochondrial function
Journal of Cardiovascular Pharmacology, Volume 63, No. 3, Year 2014
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Description
ABSTRACT:: Coronary endothelial dysfunction is involved in cardiac ischemia-reperfusion (IR) injury. Vascular endothelial growth factor (VEGF) activates endothelial cells and exerts cardioprotective effects in isolated hearts. The recently discovered viper venom protein called increasing capillary permeability protein (ICPP) exerts VEGF-like effects in endothelial cells. We examined whether VEGF or ICPP can influence IR outcome in vivo in mice. Dosages of VEGF and ICPP were determined by preliminary blood pressure study. In IR, both the proteins administered intravenously at reperfusion reduced infarct size (IS) by 57% for VEGF and 52% for ICPP (P < 0.01). Pretreatment with a selective VEGFR2 receptor antagonist abolished the reduction in IS. VEGF and ICPP induced ERK phosphorylation in the myocardium. IR triggered mitochondrial pore opening and impaired mitochondrial respiratory function. These effects of IR were prevented by VEGF or ICPP, which increased mitochondrial calcium retention capacity by 37% compared with saline (P < 0.05) and improved mitochondrial respiratory function (by 71% and 65%, respectively for state 3, and 51% and 38% for state 4, P < 0.01 for VEGF). Thus, intravenous administration of VEGF or ICPP at reperfusion largely reduces IS in IR, through stimulation of VEGFR2 receptors. This effect is mediated, at least in part, by improvement of IR-induced mitochondrial dysfunction. Copyright © 2013 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Messadi, Erij
France, Paris
Centre de Recherche Des Cordeliers
Tunisia, Tunis
Institut Pasteur de Tunis
Tunisia, Tunis
Université de Tunis el Manar
Aloui, Zohra
Tunisia, Tunis
Université de Tunis el Manar
France, Bron
Cardiovasculaire, Métabolisme, Diabétologie et Nutrition
Belaïdi, Elise
Tunisia, Tunis
Institut Pasteur de Tunis
Vincent, Marie Pascale
France, Paris
Centre de Recherche Des Cordeliers
Couture-Lepetit, Elisabeth
Tunisia, Tunis
Institut Pasteur de Tunis
Waeckel, Ludovic
France, Paris
Centre de Recherche Des Cordeliers
Decorps, Johanna
Tunisia, Tunis
Institut Pasteur de Tunis
Bouby, Nadine
France, Paris
Centre de Recherche Des Cordeliers
Gasmi, Ammar
France, Paris
Université Paris Cité
Tunisia, Tunis
Université de Tunis el Manar
France, Bron
Cardiovasculaire, Métabolisme, Diabétologie et Nutrition
Karoui, Habib
Tunisia, Tunis
Université de Tunis el Manar
France, Bron
Cardiovasculaire, Métabolisme, Diabétologie et Nutrition
Ovize, Michel
Tunisia, Tunis
Institut Pasteur de Tunis
Alhenc-Gélas, François O.
France, Paris
Centre de Recherche Des Cordeliers
Richer, Christine
France, Paris
Centre de Recherche Des Cordeliers
Statistics
Citations: 21
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1097/FJC.0000000000000045
ISSN:
01602446
e-ISSN:
15334023
Research Areas
Noncommunicable Diseases
Violence And Injury