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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Immunodepression in trypanosome‐infected mice VI. Comparison of immune responses of different lymphoid organs
European Journal of Immunology, Volume 11, No. 2, Year 1981
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Description
Mitogen stimulation of cells from various lymphoid organs of C3H/He mice chronically infected with an isolate of Trypanosoma congolense was studied at different time intervals after infection, using concanavalin A (Con A) and lipopolysaccharide (LPS). At the same time, changes in the percentages of T, B and null lymphocytes in these organs were determined by immunofluorescence staining. The responses of T and B lymphocytes in the spleen were totally depressed, and the cellular composition was drastically altered by day 14 after infection. Unlike the spleen, the lymph nodes showed minor changes in their T and B lymphocyte responses and cell composition during the course of the infection, except the B cell response and composition which were altered late in the infection. The thymus and bone marrow did not show any appreciable changes in their mitogen responses and cell composition throughout the infection. The peripheral blood lymphocytes showed reduced B cell responses. Spleen cells from chronically infected mice suppressed lymphocyte stimulation induced in normal spleen and lymph node cell populations by Con A, LPS and allogeneic stimulator cells. Lymph node cells from the same group of mice did not exhibit any such suppressor activity. In the experimental system used here, the spleen is the primary site of immune depression, and other lymphoid organs such as the lymph nodes and thymus are very little affected. Copyright © 1981 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
Authors & Co-Authors
Kar, Santosh Kumar
Kenya, Nairobi
International Laboratory for Research on Animal Diseases, Kenya
Roelants, Georges E.
Kenya, Nairobi
International Laboratory for Research on Animal Diseases, Kenya
South Africa
Centre de Recherches Sur Les Trypanosomoses Animales
Mayor-Withey, Kathleen S.
Kenya, Nairobi
International Laboratory for Research on Animal Diseases, Kenya
Pearson, Terry W.
Kenya, Nairobi
International Laboratory for Research on Animal Diseases, Kenya
Canada, Victoria
University of Victoria
Statistics
Citations: 10
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1002/eji.1830110207
e-ISSN:
15214141
Research Areas
Mental Health