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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Ontogeny of Toll-Like Receptor Mediated Cytokine Responses of South African Infants throughout the First Year of Life
PLoS ONE, Volume 7, No. 9, Article e44763, Year 2012
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Description
The first year of life represents a time of marked susceptibility to infections; this is particularly true for regions in sub-Saharan Africa. As innate immunity directs the adaptive immune response, the observed increased risk for infection as well as a suboptimal response to vaccination in early life may be due to less effective innate immune function. In this study, we followed a longitudinal cohort of infants born and raised in South Africa over the first year of life, employing the most comprehensive analysis of innate immune response to stimulation published to date. Our findings reveal rapid changes in innate immune development over the first year of life. This is the first report depicting dramatic differences in innate immune ontogeny between different populations in the world, with important implications for global vaccination strategies. © 2012 Reikie et al.
Authors & Co-Authors
Reikie, Brian
Canada, Vancouver
The University of British Columbia
Canada, Calgary
University of Calgary
Adams, Rozanne Charlene Mc Chary
South Africa, Stellenbosch
Stellenbosch University
Ruck, Candice E.
Canada, Vancouver
The University of British Columbia
Ho, Kevin
Canada, Vancouver
The University of British Columbia
Leligdowicz, Aleksandra
Canada, Vancouver
The University of British Columbia
Pillay, Santoshan
South Africa, Stellenbosch
Stellenbosch University
Naidoo, Shalena
South Africa, Stellenbosch
Stellenbosch University
Fortuno, Edgardo S.
Canada, Vancouver
The University of British Columbia
de Beer, Corena H.
South Africa, Stellenbosch
Stellenbosch University
Preiser, Wolfgang
South Africa, Stellenbosch
Stellenbosch University
Cotton, Mark Fredric
South Africa, Tygerberg
Tygerberg Hospital
Speert, David Paul
Canada, Vancouver
The University of British Columbia
Esser, Monika Maria
South Africa, Stellenbosch
Stellenbosch University
Kollmann, Tobias R.
Canada, Vancouver
The University of British Columbia
Statistics
Citations: 41
Authors: 14
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pone.0044763
e-ISSN:
19326203
Study Design
Cohort Study
Study Locations
South Africa