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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Maternal nutrition at conception modulates DNA methylation of human metastable epialleles
Nature Communications, Volume 5, Article 3746, Year 2014
Notification
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Description
In experimental animals, maternal diet during the periconceptional period influences the establishment of DNA methylation at metastable epialleles in the offspring, with permanent phenotypic consequences. Pronounced naturally occurring seasonal differences in the diet of rural Gambian women allowed us to test this in humans. We show that significant seasonal variations in methyl-donor nutrient intake of mothers around the time of conception influence 13 relevant plasma biomarkers. The level of several of these maternal biomarkers predicts increased/decreased methylation at metastable epialleles in DNA extracted from lymphocytes and hair follicles in infants postnatally. Our results demonstrate that maternal nutritional status during early pregnancy causes persistent and systemic epigenetic changes at human metastable epialleles. © 2014 Macmillan Publishers Limited.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4015319/bin/ncomms4746-s1.pdf
Authors & Co-Authors
Domínguez-Salas, Paula
United Kingdom, London
London School of Hygiene & Tropical Medicine
Moore, Sophie E.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Baker, Maria S.
United States, Houston
Usda Ars Children's Nutrition Research Center
Bergen, Andrew W.
United States, Menlo Park
Sri International
Cox, Sharon E.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Dyer, Roger A.
Canada, Vancouver
The University of British Columbia
Fulford, Anthony J.C.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Guan, Yongtao
United States, Houston
Usda Ars Children's Nutrition Research Center
United States, Houston
Baylor College of Medicine
Laritsky, Eleonora
United States, Houston
Usda Ars Children's Nutrition Research Center
Silver, Matt J.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Swan, Gary E.
United States, Palo Alto
Stanford University
Zeisel, Steven H.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Innis, Sheila Margaret
Canada, Vancouver
The University of British Columbia
Waterland, R. A.
United States, Houston
Usda Ars Children's Nutrition Research Center
United States, Houston
Baylor College of Medicine
Prentice, Andrew M.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Hennig, Branwen J.W.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Statistics
Citations: 395
Authors: 16
Affiliations: 7
Identifiers
Doi:
10.1038/ncomms4746
ISSN:
20411723
Research Areas
Food Security
Genetics And Genomics
Maternal And Child Health
Sexual And Reproductive Health
Participants Gender
Female