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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Association of a rare variant of the TNFSF13B gene with susceptibility to Rheumatoid Arthritis and Systemic Lupus Erythematosus
Scientific Reports, Volume 8, No. 1, Article 8195, Year 2018
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Description
A rare variant (BAFF-var) of the tumor necrosis factor superfamily 13b (TNFSF13B) gene has been recently associated with multiple sclerosis (MS) and systemic lupus erythematosus (SLE). The aim of this study was to investigate the association between TNFSF13B BAFF-var and susceptibility to rheumatoid arthritis (RA) and replicate that association in SLE. 6,218 RA patients, 2,575 SLE patients and 4,403 healthy controls from three different countries were included in the study. TNFSF13B BAFF-var was genotyped using TaqMan allelic discrimination assay. PLINK software was used for statistical analyses. TNFSF13B BAFF-var was significantly associated with RA (p = 0.015, OR = 1.21, 95% CI = 1.03-1.41) in the Spanish cohort. A trend of association was observed in the Dutch (p = 0.115) and German (p = 0.228) RA cohorts. A meta-analysis of the three RA cohorts included in this study revealed a statistically significant association (p = 0.002, OR = 1.24, 95% CI = 1.10-1.38). In addition, TNFSF13B BAFF-var was significantly associated with SLE in the Spanish (p = 0.001, OR = 1.41, 95% CI = 1.14-1.74) and the German cohorts (p = 0.030, OR = 1.86, 95% CI = 1.05-3.28), with a statistically significant p-value obtained in the meta-analysis (p = 0.0002, OR = 1.46, 95% CI = 1.09-2.32). The results obtained confirm the known association of TNFSF13B BAFF-var with SLE and, for the first time, demonstrate that this variant contributes to susceptibility to RA. © 2018 The Author(s).
Authors & Co-Authors
Ortiz-Fernández, Lourdes
Spain, Madrid
Consejo Superior de Investigaciones Científicas
Raya Álvarez, Enriqué G.
Unknown Affiliation
Fernàndez-Gutiérrez, Benjamín
Spain, Madrid
Hospital Clínico San Carlos
López-Longo, Francisco Javier
Spain, Madrid
Hospital General Universitario Gregorio Marañón
Balsa, Alejando
Spain, Madrid
Instituto de Investigación Sanitaria Del Hospital Universitario la Paz
Narváez, Javier A.
Spain, Barcelona
Hospital Clinic Barcelona
Gómez-Vaquero, Carmen
Spain, Barcelona
Hospital Clinic Barcelona
Sabio, José Marío
Spain, Granada
Complejo Hospitalario Universitario de Granada
Gónzalez-Escribano, María Francisca
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Carreira-Delgado, Patricia E.
Spain, Madrid
Hospital Universitario 12 de Octubre
Kiemeney, Lambertus A.L.M.
Netherlands, Nijmegen
Radboud Universiteit
Coenen, Marieke J.H.
Netherlands, Nijmegen
Radboud Universiteit
Witte, Torsten
Germany, Hannover
Hannover Medical School
Schneider, Matthias K.
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
González-Gay, Miguel Ángel
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Martin, Javier
Spain, Madrid
Consejo Superior de Investigaciones Científicas
Statistics
Citations: 13
Authors: 16
Affiliations: 15
Identifiers
Doi:
10.1038/s41598-018-26573-4
ISSN:
20452322
Research Areas
Cancer
Genetics And Genomics
Study Design
Cohort Study
Study Approach
Systematic review