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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Developmental effects of micronutrient supplementation and malaria in Zanzibari children
Early Human Development, Volume 89, No. 9, Year 2013
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Description
Background: Children's development is affected by the interplay of internal and external factors and changes in one factor can precipitate changes in multiple developmental domains. Aims: The aim of this study was to test a theoretical model of children's development using structural equation modeling. Study design: This was designed as a substudy of a randomized, placebo-controlled, 2. ×. 2 factorial trial of the effects of daily supplementation with iron (12.5. mg). +. folic acid (50. μg) (FeFA) with or without zinc (10. mg) (Zn) on child mortality. Subjects: Zanzibari children aged 5-9. mo (n. =. 106) and 10-14. mo (n. =. 141) at baseline were included in this sub study. Outcome measures: Longitudinal data on children's hemoglobin, growth, malaria infection, motor development, motor activity, and language development and caregiver behavior were used to test the fit of the theoretical model for two age groups and to examine the direct and indirect relationships among the variables in the model. Results: The theoretical models were a good fit to the data for both age groups and revealed that FeFA with or without Zn had positive effects on motor development. FeFA alone had negative effects on language development in both age groups and Zn alone had negative effects on language development in children aged 10-14. mo. The incidence of malaria had negative effects on the majority of health and development outcomes in children aged 5-9. mo, and on motor development and hemoglobin in children aged 10-14. mo. Conclusions: These findings illustrate how nutrition and health factors can affect different domains of development and how these changes can precipitate changes in other domains. More work is needed to better understand the multiple impacts of internal and external factors on children's development and how changes in developmental domains interact with each other over time to determine children's overall developmental trajectory. The randomized, placebo-controlled study was registered as an International Standard Randomized Controlled Trial, number ISRCTN59549825. © 2013 Elsevier Ireland Ltd.
Authors & Co-Authors
Olney, Deanna K.
United States, Davis
University of California, Davis
United States, Washington, D.c.
International Food Policy Research Institute
Kariger, Patricia K.
United States, Ithaca
Cornell University
Stoltzfus, Rebecca Joyce
United States, Ithaca
Cornell University
Khalfan, Sabra S.
Tanzania, Mkokotoni, Zanzibar
Pemba Public Health Laboratory
Ali, Nadra S.
Tanzania, Mkokotoni, Zanzibar
Pemba Public Health Laboratory
Tielsch, James M.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Sazawal, Sunil
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Black, Robert E.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Allen, Lindsay Helen
United States, Davis
University of California, Davis
United States, Washington, D.c.
United States Department of Agriculture
Pollitt, Ernesto
United States, Davis
University of California, Davis
Statistics
Citations: 16
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1016/j.earlhumdev.2013.04.013
ISSN:
03783782
e-ISSN:
18726232
Research Areas
Food Security
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Approach
Quantitative