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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface
Nature Communications, Volume 10, No. 1, Article 3060, Year 2019
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Description
Control of Streptococcus pneumoniae colonisation at human mucosal surfaces is critical to reducing the burden of pneumonia and invasive pneumococcal disease, interrupting transmission, and achieving herd protection. Here, we use an experimental human pneumococcal carriage model (EHPC) to show that S. pneumoniae colonisation is associated with epithelial surface adherence, micro-colony formation and invasion, without overt disease. Interactions between different strains and the epithelium shaped the host transcriptomic response in vitro. Using epithelial modules from a human epithelial cell model that recapitulates our in vivo findings, comprising of innate signalling and regulatory pathways, inflammatory mediators, cellular metabolism and stress response genes, we find that inflammation in the EHPC model is most prominent around the time of bacterial clearance. Our results indicate that, rather than being confined to the epithelial surface and the overlying mucus layer, the pneumococcus undergoes micro-invasion of the epithelium that enhances inflammatory and innate immune responses associated with clearance. © 2019, The Author(s).
Authors & Co-Authors
Weight, Caroline M.
United Kingdom, London
University College London
Venturini, Cristina
United Kingdom, London
University College London
Pojar, Sherin
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Jochems, Simon P.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Jesus, Reiné J
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Nikolaou, Elissavet
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Solórzano, Carla
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Noursadeghi, Mahdad
United Kingdom, London
University College London
Brown, Jeremy Stuart
United Kingdom, London
University College London
Ferreira, Daniela Mulari
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Heyderman, Robert Simon
United Kingdom, London
University College London
Statistics
Citations: 31
Authors: 11
Affiliations: 2
Identifiers
Doi:
10.1038/s41467-019-11005-2
ISSN:
20411723