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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selection
American Journal of Human Genetics, Volume 89, No. 3, Year 2011
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Description
The study of recent natural selection in human populations has important applications to human history and medicine. Positive natural selection drives the increase in beneficial alleles and plays a role in explaining diversity across human populations. By discovering traits subject to positive selection, we can better understand the population level response to environmental pressures including infectious disease. Our study examines unusual population differentiation between three large data sets to detect natural selection. The populations examined, African Americans, Nigerians, and Gambians, are genetically close to one another (F ST < 0.01 for all pairs), allowing us to detect selection even with moderate changes in allele frequency. We also develop a tree-based method to pinpoint the population in which selection occurred, incorporating information across populations. Our genome-wide significant results corroborate loci previously reported to be under selection in Africans including HBB and CD36. At the HLA locus on chromosome 6, results suggest the existence of multiple, independent targets of population-specific selective pressure. In addition, we report a genome-wide significant (p = 1.36 × 10 -11) signal of selection in the prostate stem cell antigen (PSCA) gene. The most significantly differentiated marker in our analysis, rs2920283, is highly differentiated in both Africa and East Asia and has prior genome-wide significant associations to bladder and gastric cancers. © 2011 The American Society of Human Genetics.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3169818/bin/mmc1.pdf
Authors & Co-Authors
Bhatia, Gaurav
United States, Cambridge
Massachusetts Institute of Technology
Patterson, Nick J.
United States, Cambridge
Massachusetts Institute of Technology
Paşaniuc, Bogdan
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard T.h. Chan School of Public Health
Zaitlen, Noah A.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard T.h. Chan School of Public Health
Genovese, Giulio
United States, Boston
Harvard Medical School
Pollack, Samuela
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard T.h. Chan School of Public Health
Mallick, Swapan
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
Myers, Simon R.
United Kingdom, Oxford
University of Oxford
Tandon, Arti
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
Spencer, Chris C.A.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Palmer, Cameron D.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Boston Children's Hospital
Adeyemo, Adebowale A.
United States, Bethesda
National Human Genome Research Institute Nhgri
Akylbekova, Ermeg L.
United States, Jackson
Jackson State University
Cupples, Laura Adrienne
United States, Boston
Boston University
Divers, Jasmin
United States, Winston Salem
Wake Forest University
Fornage, Myriam
United States, Houston
University of Texas School of Public Health
Kao, Wenhong Linda
United States, Baltimore
Johns Hopkins University
United States, Baltimore
Welch Center for Prevention Epidemiology and Clinical Research
Lange, Leslie A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Li, Mingyao
United States, Philadelphia
University of Pennsylvania
Musani, Solomon K.
United States, Jackson
University of Mississippi Medical Center
Mychaleckyj, Josyf C.
United States, Charlottesville
University of Virginia School of Medicine
Ogunniyi, Adesola O.
Nigeria, Ibadan
University of Ibadan
Papanicolaou, George John
United States, Bethesda
National Heart, Lung, and Blood Institute Nhlbi
Rotimi, Charles N.
United States, Bethesda
National Human Genome Research Institute Nhgri
Rotter, Jerome I.
United States, Los Angeles
Cedars-sinai Medical Center
Ruczinski, Ingo
United States, Baltimore
Johns Hopkins University
Salako, Babatunde Lawal
Nigeria, Ibadan
University of Ibadan
Siscovick, David S.
United States, Seattle
University of Washington
United States, Seattle
University of Washington School of Medicine
Tayo, Bamidele O.
United States, Maywood
Loyola University Stritch School of Medicine
Yang, Qiong
United States, Boston
Boston University
McCarroll, Steven A.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
Sabeti., Pardis C.
United States, Cambridge
Harvard University
Lettre, Guillaume
Canada, Montreal
Institut de Cardiologie de Montreal
Canada, Montreal
University of Montreal
de Jager, Philip Lawrence
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Brigham and Women's Hospital
United States, Cambridge
Partners Healthcare Personalized Medicine
Hirschhorn, Joel N.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Boston Children's Hospital
Xiaofeng, Zhu
United States, Cleveland
Case Western Reserve University
Cooper, Richard S.
United States, Maywood
Loyola University Stritch School of Medicine
Reich, David E.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
Wilson, James Gaines
United States, Jackson
University of Mississippi Medical Center
Price, Alkes L.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard T.h. Chan School of Public Health
Statistics
Citations: 93
Authors: 40
Affiliations: 29
Identifiers
Doi:
10.1016/j.ajhg.2011.07.025
ISSN:
00029297
e-ISSN:
15376605
Research Areas
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study
Cohort Study