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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Role of N-methyl-d-aspartate and opiate receptors in nociception during and after ischaemia in rats
Pain, Volume 49, No. 2, Year 1992
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Description
We have investigated the effects of systemic administration of two N-methyl-d-aspartate (NMDA) receptor antagonists and two opiate agonists on nociception during and after tail ischaemia in conscious rats. The two NMDA receptor antagonists, d-2-amino-5-phosphonovalerate (APV) and ketamine hydrochloride, did not alter tail flick latencies in rats not subjected to ischaemia but inhibited post-ischaemic hyperalgesia (PIH) in a dose-dependent manner. Neither of these agents impaired motor function of the rats, as assessed by rotarod performance, suggesting a purely sensory antinociceptive effect. The antinociceptive effect of APV during reperfusion following ischaemia was not antagonised by the μ-opiate receptor antagonist naloxone (1 mg/kg). The two opiate receptor agonists, morphine and pethidine, increased tail flick latencies in rats not subjected to ischaemia, inhibited PIH in a dose-dependent manner, and also caused significant motor malfunction, all in naloxone-reversible fashion. We conclude that the role of the NMDA receptor in mediating afferent nociceptive traffic is confined to its involvement in neuronal events mediating hyperalgesia. © 1992.
Authors & Co-Authors
Sher, Graham D.
South Africa, Johannesburg
School of Clinical Medicine
Cartmell, Steven M.
South Africa, Johannesburg
School of Clinical Medicine
Gelgor, Linda
South Africa, Johannesburg
School of Clinical Medicine
Mitchell, Duncan
South Africa, Johannesburg
School of Clinical Medicine
Statistics
Citations: 54
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1016/0304-3959(92)90148-5
ISSN:
03043959