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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Genomic study of the response of chicken to highly pathogenic avian influenza virus
BMC Proceedings, Volume 5, Article s25, Year 2011
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Description
Background: The host mounts an immune response to pathogens, but few data are currently available on the role of host genetics in variation in response to avian influenza (AI). The study presented here investigated the role of the host genetic background in response to in vivo infection with AI virus (AIV). Methods: Experimental lines of chicken and commercial crosses were experimentally infected intratracheally with 103 EID50/bird of A/Chicken/Italy/13474/99 H7N1 highly pathogenic avian influenza virus (HPAIV). Chickens were genotyped for the Mx polymorphism causing the S631N mutation, and for the Major Histocompatibility Complex (MHC). Whole-genome genotyping was carried out using 60 k Single Nucleotide Polymorphism (SNP) array developed by the poultry Genome-Wide Marker-Assisted Selection Consortium (GWMASC). Results: Variability in response of different chicken lines to the HPAIV infections and some degree of resistance to AI were observed: a statistically significant effect of chicken line on the response to infection was found. There was no association between survival in healthy conditions and polymorphisms at the Mx gene and the MHC-B region. The analysis based on the 60 k SNPs provided a good clustering of the chicken lines, but no specific genetic cluster associated with response to AIV was identified. Conclusions: Neither the genotype at the Mx gene or MHC-B locus, nor for SNP spanning the whole-genome identified loci involved in variations to response to AIV infection. These results point towards the possibility that either the genetic factors affecting the response of chickens to the H7N1 HPAIV are weak, or relevant alleles were not segregating in the studied populations. © 2011 Sironi et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Williams, John Lewis
Italy, Lodi
Parco Tecnologico Padano
Stella, Alessandra
Italy, Lodi
Parco Tecnologico Padano
Italy, Lodi
Ibba-cnr
Minozzi, Giulietta
Italy, Lodi
Parco Tecnologico Padano
Moreno, Ana M.
Italy, Brescia
Istituto Zooprofilattico Sperimentale Della Lombardia e Dell'emilia Romagna Bruno Ubertini
Han, Jianlin
China, Beijing
Chinese Academy of Agricultural Sciences
Weigend, Steffen
Germany, Tubingen
Friedrich-loeffler-institute
Cordioli, Paolo
Italy, Brescia
Istituto Zooprofilattico Sperimentale Della Lombardia e Dell'emilia Romagna Bruno Ubertini
Mariani, Paola
Italy, Lodi
Parco Tecnologico Padano
Statistics
Citations: 18
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1186/1753-6561-5-S4-S25
ISSN:
17536561
Research Areas
Cancer
Genetics And Genomics