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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Sirolimus-eluting and paclitaxel-eluting stents for the treatment of coronary bifurcations
American Heart Journal, Volume 156, No. 4, Year 2008
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Description
Background: The aim of the study was to compare the outcomes of sirolimus-eluting (SES) and paclitaxel-eluting (PES) stent implantation in coronary bifurcations treated with either a 1-stent or 2-stent strategy. Methods: The study used a retrospective cohort analysis of consecutive de novo bifurcations, excluding left main, treated with SES or PES between April 2003 and June 2005. Results: We identified 170 bifurcations in 161 patients treated with SES and 119 bifurcations in 112 patients treated with PES. During a median follow-up of 1,061 days (interquartile range 814-1,314), 43 patients (26.7%) in the SES group and 28 (25.0%) in the PES group had a major adverse cardiac event (P = .78). The angiographic restenosis rate per bifurcation was 20.9% and 25.9%, respectively (P = .41). There was no difference overall in the occurrence of target lesion revascularization (TLR) per bifurcation, 22 with SES (12.9%) and 18 with PES (15.1%), P = .61. The TLR rate was similar for SES and PES in bifurcations treated with 1 stent (6.7% vs 11.4%, P = .40) and in bifurcations treated with both branch stenting (20.0% vs 20.4%, P =1.0). Conclusions: In this cohort, the long-term clinical outcomes appear similar overall between SES and PES in the treatment of coronary bifurcations irrespective of whether a 1-stent or 2-stent strategy was used. © 2008 Mosby, Inc. All rights reserved.
Authors & Co-Authors
Latib, Azeem M.
Italy, Milan
Irccs Ospedale San Raffaele
South Africa, Cape Town
University of Cape Town
Cosgrave, John V.
Italy, Milan
Emo Centro Cuore Columbus
Godino, Cosmo
Italy, Milan
Irccs Ospedale San Raffaele
Qasim, Asif
Italy, Milan
Emo Centro Cuore Columbus
Corbett, Simon J.
Italy, Milan
Emo Centro Cuore Columbus
Tavano, Davide
Italy, Milan
Irccs Ospedale San Raffaele
Morici, Nuccia
Italy, Milan
Irccs Ospedale San Raffaele
Cristell, Nicole A.
Italy, Milan
Irccs Ospedale San Raffaele
Chieffo, Alaide
Italy, Milan
Irccs Ospedale San Raffaele
Carlino, Mauro
Italy, Milan
Irccs Ospedale San Raffaele
Montorfano, Matteo
Italy, Milan
Irccs Ospedale San Raffaele
Airoldi, Flavio
Italy, Milan
Irccs Ospedale San Raffaele
Italy, Milan
Emo Centro Cuore Columbus
Colombo, Antonio
Italy, Milan
Irccs Ospedale San Raffaele
Italy, Milan
Emo Centro Cuore Columbus
Statistics
Citations: 28
Authors: 13
Affiliations: 3
Identifiers
Doi:
10.1016/j.ahj.2008.05.024
ISSN:
00028703
e-ISSN:
10976744
Research Areas
Noncommunicable Diseases
Study Design
Cohort Study