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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Longitudinal study of urban malaria in a cohort of Ugandan children: Description of study site, census and recruitment
Malaria Journal, Volume 5, Article 18, Year 2006
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Description
Background: Studies of malaria in well-defined cohorts offer important data about the epidemiology of this complex disease, but few have been done in urban African populations. To generate a sampling frame for a longitudinal study of malaria incidence and treatment in Kampala, Uganda, a census, mapping and survey project was conducted. Methods: All households in a geographically defined area were enumerated and mapped. Probability sampling was used to recruit a representative sample of children and collect baseline descriptive data for future longitudinal studies. Results: 16,172 residents living in 4931 households in a densely-populated community (18,824 persons/km2) were enumerated. A total of 582 households were approached with at least one child less than 10 years of age in order to recruit 601 children living in 322 households. At enrollment, 19% were parasitaemic, 24% were anaemic, 43% used bednets, and 6% used insecticide-treated nets. Low G6PD activity (OR = 0.33, P = 0.009) and bednet use (OR = 0.64, P = 0.045) were associated with a decreased risk of parasitaemia. Increasing age (OR = 0.62 for each year, P < 0.001) and bednet use (OR = 0.58, P = 0.02) were associated with a decreased risk of anaemia Conclusion: Detailed surveys of target populations in urban Africa can provide valuable descriptive data and provide a sampling frame for recruitment of representative cohorts for longitudinal studies. Plans to use a multi-disciplinary approach to improve the understanding of the distribution and determinants of malaria incidence and response to therapy in this population are discussed. © 2006Davis et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Davis, Jennifer Clare
United States, San Francisco
Ucsf School of Medicine
Clark, Tamara D.
United States, San Francisco
Ucsf School of Medicine
Kemble, Sarah K.
United States, San Francisco
Ucsf School of Medicine
Nalugwa, Talemwa K.
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Njama-Meya, Denise
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Staedke, Sarah G.
United States, San Francisco
Ucsf School of Medicine
Dorsey, Grant M.
United States, San Francisco
Ucsf School of Medicine
Statistics
Citations: 55
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1186/1475-2875-5-18
ISSN:
14752875
e-ISSN:
14752875
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Uganda