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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The impact of macular pigment augmentation on visual performance in normal subjects: COMPASS
Vision Research, Volume 51, No. 5, Year 2011
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Description
This study was conducted to investigate whether augmentation of macular pigment (MP) enhances visual performance (VP). 121 normal subjects were recruited. The active (A) group consumed 12. mg of lutein (L) and 1. mg of zeaxanthin (Z) daily. MP optical density (MPOD) was assessed by customized heterochromatic flicker photometry. VP was assessed as best corrected visual acuity (BCVA), mesopic and photopic contrast sensitivity (CS), glare disability, photostress, and subjective visual function. Subjects were assessed at baseline; 3; 6; 12. months (V1, V2, V3 and V4, respectively). Central MPOD increased significantly in the A group (p< 0.05) but not in the placebo group (p> 0.05). This statistically significant increase in MPOD in the A group was not, in general, associated with a corresponding improvement in VP (p> 0.05, for all variables), with the exception of a statistically significant time/treatment effect in " daily tasks comparative analysis" (p= 0.03). At V4, we report statistically significant differences in mesopic CS at 20.7. cpd, mesopic CS at 1.5. cpd under high glare conditions, and light/dark adaptation comparative analysis between the lower and the upper MP tertile groups (p< 0.05) Further study into the relationship between MP and VP is warranted, with particular attention directed towards individuals with low MP and suboptimal VP. © 2011 Elsevier Ltd.
Authors & Co-Authors
Nolan, John Michael
Ireland, Waterford
South East Technological University
Loughman, James J.
Ireland, Dublin
Technological University Dublin
Akkali, Mukunda Chaitanya
Ireland, Waterford
South East Technological University
Stack, Jim
Ireland, Waterford
South East Technological University
Scanlon, Grainne
Ireland, Dublin
Technological University Dublin
Davison, Peter A.
Ireland, Dublin
Technological University Dublin
Statistics
Citations: 93
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.visres.2010.12.016
ISSN:
00426989
Research Areas
Disability
Study Design
Quasi Experimental Study