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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Subsquamous extension of intestinal metaplasia is detected in 98% of cases of neoplastic Barrett's esophagus
Clinical Gastroenterology and Hepatology, Volume 12, No. 3, Year 2014
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Description
Background & Aims: Subsquamous intestinal metaplasia (SSIM) has been observed after endotherapy in patients with neoplastic Barrett's esophagus (BE). However, it is not clear whether SSIM occurs in untreated patients. Incompletely eradicated SSIM could provide a source of recurrent disease. We assessed its prevalence in a large cohort of patients who had not received endoscopic therapy. Methods: Two experienced pathologists analyzed 138 samples of 506 resection specimens found to contain squamous epithelium from 110 patients with neoplastic BE treated by widespread endoscopic mucosal resection (92 men; mean age, 66 years). The maximum extent of SSIM was measured. Results: Of the 138 samples analyzed, 124 (89.9%) were found to contain SSIM from 108 of the 110 patients (98.2%). The mean length of SSIM was 3.3 mm (range, 0.2-9.6 mm; 25% ≥5 mm); SSIM length correlated with BE length (P < .05). In 83 of 138 samples (60.1%), the SSIM consisted partially or entirely of neoplasias of different grades, with a mean subsquamous extension of 3.3 mm; the extension correlated with grade of neoplasia (P= .0001). Conclusions: Most patients with BE with neoplasia (of all grades) have subsquamous extension of intestinal metaplasia, including subsquamous extension of lesions at the squamocolumnar junction. Therefore, biopsy and resection of neoplastic BE should extend at least 1 cm into the squamous epithelium. © 2014 AGA Institute.
Authors & Co-Authors
Anders, Mario
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Lucks, Yasmin
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
El-Masry, Muhammad Abbas
Egypt, Asyut
Assiut University
Quaas, Alexander
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Ros̈ch, Thomas
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Schachschal, Guido
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Bähr, Christina
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Gauger, Ulrich
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Sauter, Guido
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Izbicki, Jakob Robert
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Marx, Andreas Holger
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Statistics
Citations: 37
Authors: 11
Affiliations: 2
Identifiers
Doi:
10.1016/j.cgh.2013.07.013
ISSN:
15423565
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Male