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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
No evidence of delayed parasite clearance after oral artesunate treatment of uncomplicated falciparum malaria in Mali
American Journal of Tropical Medicine and Hygiene, Volume 87, No. 1, Year 2012
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Description
Plasmodium falciparum resistance to artemisinins by delayed parasite clearance is present in Southeast Asia. Scant data on parasite clearance after artemisinins are available from Africa, where transmission is high, burden is greatest, and artemisinin use is being scaled up. Children 1-10 years of age with uncomplicated malaria were treated with 7 days of artesunate and followed for 28 days. Blood smears were done every 8 hours until negative by light microscopy. Results were compared with a similar study conducted in the same village in 2002-2004. The polymerase chain reactioncorrected cure rate was 100%, identical to 2002-2004. By 24 hours after treatment initiation, 37.0% of participants had cleared parasitemia, compared with 31.9% in 2002-2004 (P = 0.5). The median parasite clearance time was 32 hours. Only one participant still had parasites at 48 hours and no participant presented parasitemia at 72 hours. Artesunate was highly efficacious, with no evidence of delayed parasite clearance. We provide baseline surveillance data for the emergence or dissemination of P. falciparum resistance in sub-Saharan Africa. Copyright © 2012 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Maiga, Amelia Walling
United States, Durham
Duke University School of Medicine
Fofana, Bakary
Mali, Bamako
University of Bamako
Sagara, Issaka
Mali, Bamako
University of Bamako
Dembele, Demba
Mali, Bamako
University of Bamako
Dara, Antoine
Mali, Bamako
University of Bamako
Traoré, Oumar Bila
Mali, Bamako
University of Bamako
Toure, Sékou
Mali, Bamako
University of Bamako
Sanogo, Kassim
Mali, Bamako
University of Bamako
Dama, Souleymane
Mali, Bamako
University of Bamako
Sidibé, Bakary
Mali, Bamako
University of Bamako
Koné, Aminatou K.
Mali, Bamako
University of Bamako
Thera, Mahamadou Ali
Mali, Bamako
University of Bamako
Plowe, Christopher Vv
United States, Baltimore
University of Maryland School of Medicine
Doumbo, Ogobara K.
Mali, Bamako
University of Bamako
Djimde, Abdoulaye A.
Mali, Bamako
University of Bamako
Statistics
Citations: 69
Authors: 15
Affiliations: 3
Identifiers
Doi:
10.4269/ajtmh.2012.12-0058
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Locations
Mali